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444965 MEK Inhibitor VIII - CAS 212631-61-3 - Calbiochem

444965
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical FormulaCAS #
C₁₈H₁₆F₃IN₂O₂ 212631-61-3

Products

Numero di catalogoConfezionamento Qtà/conf
444965-5MG Fiala di plastica 5 mg
Description
OverviewA cell-permeable and orally available amino-benzamide compound that acts as a potent and non-ATP-competitive inhibitor of MEK1/2 (IC50 = 8 nM) with an excellent selectivity over ERK, c-Src, Cdk's, and PI 3-Kγ (IC50 >1.0 µM). Reported to exhibit in vivo efficacy in several animal models of arthritis and hyperalgesia in rat and rabbit.
Catalogue Number444965
Brand Family Calbiochem®
SynonymsN-Cyclopropylmethoxy-3,4,5-trifluoro-2-(4-iodo-2-methylphenylamino)benzamide
References
ReferencesPelletier, J.P., et al. 2003. Arthritis Rheum. 48, 1582.
Ciruela, A., et al. 2003. Br. J. Pharmacol. 138, 751.
Bhattachar, S.N., et al. 2002. Int. J. Pharm. 236, 135.
Product Information
CAS number212631-61-3
FormWhite solid
Hill FormulaC₁₈H₁₆F₃IN₂O₂
Chemical formulaC₁₈H₁₆F₃IN₂O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25-36/37/39

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

MEK Inhibitor VIII - CAS 212631-61-3 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

MEK Inhibitor VIII - CAS 212631-61-3 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
444965

Riferimenti bibliografici

Panoramica delle referenze
Pelletier, J.P., et al. 2003. Arthritis Rheum. 48, 1582.
Ciruela, A., et al. 2003. Br. J. Pharmacol. 138, 751.
Bhattachar, S.N., et al. 2002. Int. J. Pharm. 236, 135.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-December-08 RFH
SynonymsN-Cyclopropylmethoxy-3,4,5-trifluoro-2-(4-iodo-2-methylphenylamino)benzamide
DescriptionA cell-permeable and orally available amino-benzamide compound that acts as a potent and non-ATP-competitive inhibitor of MEK1/2 (IC50 = 8 nM) with an excellent selectivity over ERK, c-Src, Cdk's, and PI 3-Kγ (IC50 >1.0 µM). Reported to exhibit in vivo efficacy in several animal models of arthritis and hyperalgesia in rat and rabbit.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number212631-61-3
Chemical formulaC₁₈H₁₆F₃IN₂O₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (45 mg/ml) or Ethanol (45 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesPelletier, J.P., et al. 2003. Arthritis Rheum. 48, 1582.
Ciruela, A., et al. 2003. Br. J. Pharmacol. 138, 751.
Bhattachar, S.N., et al. 2002. Int. J. Pharm. 236, 135.