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475730 MRP1 Inhibitor II, Reversan - Calbiochem

475730
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₂₆H₂₇N₅O₂

Products

Numero di catalogoConfezionamento Qtà/conf
475730-10MG 10 mg
Description
OverviewA cell-permeable pyrazolopyrimidine that selectively inhibits MRP1. It is shown to increase the efficacy of vincristine and etopiside by 10- to 15-fold and 7- to 10-fold, respectively, over either of these two MRP1 substrate drugs alone in murine models of neuroblastoma (syngenic and human xenografts). As opposed to the majority of inhibitors of multidrug transporters, it is demonstrated that Reversan was not toxic by itself nor did it increase the toxicity of chemotherapeutic drug exposure in mice. Therefore, Reversan represents a new class of nontoxic MRP1 inhibitor, which may be a useful research tool for the study of neuroblastoma and other MRP1-overexpressing drug-refractory tumors.
Catalogue Number475730
Brand Family Calbiochem®
SynonymsMultidrug Resistance Protein 1 Inhibitor, Reversan
References
ReferencesBurkhart, C.A., et al. 2009. Cancer Res. 69, 6573.
Product Information
FormPale yellow solid
Hill FormulaC₂₆H₂₇N₅O₂
Chemical formulaC₂₆H₂₇N₅O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

MRP1 Inhibitor II, Reversan - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

MRP1 Inhibitor II, Reversan - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
475730

Riferimenti bibliografici

Panoramica delle referenze
Burkhart, C.A., et al. 2009. Cancer Res. 69, 6573.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-December-2010 RFH
SynonymsMultidrug Resistance Protein 1 Inhibitor, Reversan
DescriptionA cell-permeable pyrazolopyrimidine that selectively inhibits MRP1. It is shown to increase the efficacy of vincristine and etopiside by 10- to 15-fold and 7- to 10-fold, respectively, over either of these two MRP1 substrate drugs alone in murine models of neuroblastoma (syngenic and human xenografts). As opposed to the majority of inhibitors of multidrug transporters, it is demonstrated that Reversan was not toxic by itself nor did it increase the toxicity of chemotherapeutic drug exposure in mice. Therefore, Reversan represents a new class of nontoxic MRP1 inhibitor, which may be a useful research tool for the study of neuroblastoma and other MRP1-overexpressing drug-refractory tumors.
FormPale yellow solid
Chemical formulaC₂₆H₂₇N₅O₂
Structure formulaStructure formula
SolubilityDMSO (10 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBurkhart, C.A., et al. 2009. Cancer Res. 69, 6573.