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444130 Mcl-1 Inhibitor, MIM1 - Calbiochem

444130
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Panoramica

Replacement Information

Products

Numero di catalogoConfezionamento Qtà/conf
444130-25MG Bottiglia di vetro 25 mg
Description
OverviewA cell-permeable thiazolyliminopyrogallol that selectively neutralizes Mcl-1, but not Bcl-XL, antiapoptotic activity by directly targeting Mcl-1 BH3-binding site, effectively competing against Bid BH3 sequence for Mcl-1 binding (IC50 = 4.8 µM). Shown to induce caspase 3/7 activation and cell death in Mcl-1-, but not Bcl-XL-, dependent B-ALL cultures (6% vs. 82% survival, respectively; 10 µM). In comparison, ABT-737 (Cat. No. 197333) affects only Bcl-XL-, but not Mcl-1-, dependent B-ALL cells. Neither MIM1 nor ABT-737 significantly affects the survival of wild-type or Bax-/-Bak-/- MEF.
Catalogue Number444130
Brand Family Calbiochem®
Synonyms4-((E)-((Z)-2-(cyclohexylimino)-4-methylthiazol-3(2H)-ylimino)methyl)benzene-1,2,3-triol, Mcl-1 Inhibitor Molecule 1
References
ReferencesCohen, N.A., et al. 2012. Chem. Biol. 19, 1175.
Product Information
FormYellow powder
Hill FormulaC₁₇H₂₁N₃O₃S
Chemical formulaC₁₇H₂₁N₃O₃S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMcl-1
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Mcl-1 Inhibitor, MIM1 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
444130

Riferimenti bibliografici

Panoramica delle referenze
Cohen, N.A., et al. 2012. Chem. Biol. 19, 1175.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-July-2013 JSW
Synonyms4-((E)-((Z)-2-(cyclohexylimino)-4-methylthiazol-3(2H)-ylimino)methyl)benzene-1,2,3-triol, Mcl-1 Inhibitor Molecule 1
DescriptionA cell-permeable thiazolyliminopyrogallol that selectively neutralizes Mcl-1, but not Bcl-XL, antiapoptotic activity, by directly targeting Mcl-1 BH3-binding site, effectively competing against Bid BH3 sequence for Mcl-1 binding (IC50 = 4.8 µM) without affecting Bcl-XL interaction with Bad or Bid BH3 sequence (IC50 >50 µM). Shown to induce caspase 3/7 activation and cell death in Mcl-1-, but not Bcl-XL-, dependent B-ALL cultures (6% vs. 82% survival, respectively, [MIM1] = 10 µM). In comparison, ABT-737 (Cat. No. 197333) affects only Bcl-XL-, but not Mcl-1-, dependent B-ALL cultures (0% vs. 98% survival, respectively, [ABT-737] = 10 µM). Neither MIM1 nor ABT-737 significantly affects the survival of wild-type (81% and 79% survival in the presence of 10 µM respective inhibitor) or Bax-/-Bak-/- MEF (93% and 84% survival in the presence of 10 µM respective inhibitor).
FormYellow powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₇H₂₁N₃O₃S
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (50 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesCohen, N.A., et al. 2012. Chem. Biol. 19, 1175.