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445820 Meriolin 2 - Calbiochem

445820
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₁₁H₉N₅O

Products

Numero di catalogoConfezionamento Qtà/conf
445820-5MG Fiala di plastica 5 mg
Description
OverviewA cell-permeable, ATP-binding site-targeting azaindolopyrimidine compound that inhibits against Cdk2/A, Cdk9/T, DYRK1A, Cdk5/p25, CK1δ/ε, Cdk1/B, and GSK-3α/β kinase activity (IC50 = 18, 18, 35, 50, 50, 57, and 500 nM, respectively). Shown to induce DEVDase activity in SH-SY5Y neuroblastoma cultures (by 5.46-fold in 24 h at 1 µM) and exhibit antiproliferative activity toward SH-SY5Y, multiple myeloma KMS-11, human embryonic kidney HEK293, colorectal adenocarcinoma LS 174T, and glioma GBM cells in vitro (IC50 = 0.41, 0.6, 0.96, 1.06, and 1.21 µM, respectively).
Catalogue Number445820
Brand Family Calbiochem®
Synonyms3-((2-Amino)pyrimidin-4-yl)-4-hydroxy-1H-pyrrolo[2,3-b]pyridine
References
ReferencesEchalier, A., et al. 2008. J. Med. Chem. 51, 737.
Bettayeb, K., et al. 2007. Cancer Res. 67, 8325.
Product Information
FormYellow solid
Hill FormulaC₁₁H₉N₅O
Chemical formulaC₁₁H₉N₅O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥93% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Meriolin 2 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Meriolin 2 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
445820

Riferimenti bibliografici

Panoramica delle referenze
Echalier, A., et al. 2008. J. Med. Chem. 51, 737.
Bettayeb, K., et al. 2007. Cancer Res. 67, 8325.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-March-2011 RFH
Synonyms3-((2-Amino)pyrimidin-4-yl)-4-hydroxy-1H-pyrrolo[2,3-b]pyridine
DescriptionA cell-permeable, ATP-binding site-targeting azaindolopyrimidine compound that inhibits against Cdk2/A, Cdk9/T, DYRK1A, Cdk5/p25, CK1δ/ε, Cdk1/B, and GSK-3α/β kinase activity (IC50 = 18, 18, 35, 50, 50, 57, and 500 nM, respectively). Shown to induce DEVDase activity in SH-SY5Y neuroblastoma cultures (by 5.46-fold in 24 h at 1 µM) and exhibit antiproliferative activity toward SH-SY5Y, multiple myeloma KMS-11, human embryonic kidney HEK293, colorectal adenocarcinoma LS 174T, and glioma GBM cells in vitro (IC50 = 0.41, 0.6, 0.96, 1.06, and 1.21 µM, respectively).
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₁H₉N₅O
Structure formulaStructure formula
Purity≥93% by HPLC
SolubilityDMSO (50 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Regulatory Review
ReferencesEchalier, A., et al. 2008. J. Med. Chem. 51, 737.
Bettayeb, K., et al. 2007. Cancer Res. 67, 8325.