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445888 Metastin (45-54) - Calbiochem

445888
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₆₃H₈₃N₁₇O₁₄

Products

Numero di catalogoConfezionamento Qtà/conf
445888-1MG Fiala di plastica 1 mg
Description
OverviewA decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors). Induces an increase in intracellular Ca2+ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells and exhibits about 8-fold higher receptor binding affinity (Ki = 42 pM) compared to Metastin (Cat. No. 445885).
Catalogue Number445888
Brand Family Calbiochem®
SynonymsKiSS-1 (112-121), Kisspeptin-10, H-YNWNSFGLRF-NH₂
References
ReferencesKotani, M., et al. 2001. J. Biol. Chem. 276, 34631.
Ohtaki, T., et al. 2001. Nature 411, 613.
Muir, A.I., et al. 2001. J. Biol. Chem. 276, 28969.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₆₃H₈₃N₁₇O₁₄
Chemical formulaC₆₃H₈₃N₁₇O₁₄
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
ApplicationMetastin (45-54), CAS 374675-21-5, is a decapeptide that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors).
Biological Information
Primary TargetAXOR12 and hOT7T175
Primary Target K<sub>i</sub>42 pM for AXOR12 and hOT7T175
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Metastin (45-54) - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Metastin (45-54) - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
445888

Riferimenti bibliografici

Panoramica delle referenze
Kotani, M., et al. 2001. J. Biol. Chem. 276, 34631.
Ohtaki, T., et al. 2001. Nature 411, 613.
Muir, A.I., et al. 2001. J. Biol. Chem. 276, 28969.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-August-2008 RFH
SynonymsKiSS-1 (112-121), Kisspeptin-10, H-YNWNSFGLRF-NH₂
DescriptionA decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptor). More potent than the parent peptide. Induces an increase in intracellular Ca2+ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells and exhibits about 8-fold higher receptor binding affinity (Ki = 42 pM, determined by competitive binding analysis) as compared to Metastin (Cat. No. 444885).
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₆₃H₈₃N₁₇O₁₄
Peptide SequenceH-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesKotani, M., et al. 2001. J. Biol. Chem. 276, 34631.
Ohtaki, T., et al. 2001. Nature 411, 613.
Muir, A.I., et al. 2001. J. Biol. Chem. 276, 28969.