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475872 MnTMPyP - Calbiochem

475872
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₇₂H₆₅MnN₈O₁₃S₄

Products

Numero di catalogoConfezionamento Qtà/conf
475872-25MG Fiala di plastica 25 mg
Description
OverviewCell-permeable superoxide dismutase (SOD) mimetic. Catalyzes the dismutation of O2– • (rate constant ~4 x 107 M-1 s-1) even in the presence of excess EDTA. Can substitute for SOD in mutants of E. coli lacking this enzyme. MnTMPyP acts in vivo as an NADPH/GSH:O2 oxidoreductase rather than as an SOD mimetic. Also an efficient peroxynitrite reductase when redox-coupled with biological antioxidants.
Catalogue Number475872
Brand Family Calbiochem®
SynonymsMn(III)tetrakis(1-methyl-4-pyridyl)porphyrin, Tetratosylate, Hydroxide
References
ReferencesIzbicka, E., et al. 1999. Cancer Res. 59, 639.
Lee, J., et al. 1998. J. Am. Chem. Soc. 120, 6053.
Gardner, P.R., et al. 1996. Arch. Biochem. Biophys. 325, 20.
Liochev, S.I., and Fridovich, I. 1995. Arch. Biochem. Biophys. 321, 271.
Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.
Product Information
ATP CompetitiveN
FormBlack solid
Hill FormulaC₇₂H₆₅MnN₈O₁₃S₄
Chemical formulaC₇₂H₆₅MnN₈O₁₃S₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetSuperoxide dismutase (SOD) mimetic
Purity≥95% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

MnTMPyP - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

MnTMPyP - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
475872

Riferimenti bibliografici

Panoramica delle referenze
Izbicka, E., et al. 1999. Cancer Res. 59, 639.
Lee, J., et al. 1998. J. Am. Chem. Soc. 120, 6053.
Gardner, P.R., et al. 1996. Arch. Biochem. Biophys. 325, 20.
Liochev, S.I., and Fridovich, I. 1995. Arch. Biochem. Biophys. 321, 271.
Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.

Brochure

Titolo
Pathways and Biomarkers of Oxidative Stress

Citazioni

Titolo
  • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
  • Scheda tecnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision15-August-2008 JSW
    SynonymsMn(III)tetrakis(1-methyl-4-pyridyl)porphyrin, Tetratosylate, Hydroxide
    DescriptionCell-permeable superoxide dismutase (SOD) mimetic. Catalyzes the dismutation of O2– • (rate constant ~4 x 107 M-1 s-1) even in the presence of excess EDTA. Can substitute for SOD in mutants of E. coli lacking this enzyme. MnTMPyP acts in vivo as an NADPH/GSH:O2 oxidoreductase rather than as an SOD mimetic. Also an efficient peroxynitrite reductase when redox-coupled with biological antioxidants.
    FormBlack solid
    Chemical formulaC₇₂H₆₅MnN₈O₁₃S₄
    Structure formulaStructure formula
    Purity≥95% by TLC
    SolubilityH₂O (1 mg/ml)
    Storage -20°C
    Protect from moisture
    Protect from light
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    Toxicity Standard Handling
    ReferencesIzbicka, E., et al. 1999. Cancer Res. 59, 639.
    Lee, J., et al. 1998. J. Am. Chem. Soc. 120, 6053.
    Gardner, P.R., et al. 1996. Arch. Biochem. Biophys. 325, 20.
    Liochev, S.I., and Fridovich, I. 1995. Arch. Biochem. Biophys. 321, 271.
    Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.
    Citation
  • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.