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495320 ODQ - CAS 41443-28-1 - Calbiochem

495320
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
41443-28-1C₉H₅N₃O₂

Products

Numero di catalogoConfezionamento Qtà/conf
495320-10MG Fiala di plastica 10 mg
Description
OverviewA cell-permeable, potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC50 = 20 nM). In incubated cerebellum slices, ODQ reversibly inhibits the NO-dependent cGMP response to glutamate receptor agonists without affecting NOS activity. It does not chemically inactivate NO; however, it does inhibit cGMP generation in response to NO donors. ODQ does not inhibit NO-mediated macrophage toxicity, a phenomenon unrelated to cGMP, nor does it affect the activity of particulate guanylyl cyclase or adenylyl cyclase.
Catalogue Number495320
Brand Family Calbiochem®
Synonyms1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
References
ReferencesWang, D., et al. 1998. J. Biol. Chem. 273, 33027.
Southam, E., et al. 1996. Br. J. Pharmacol. 119, 527.
Brunner, F., et al. 1995. FEBS Lett. 376, 262.
Garthwaite, J., et al. 1995. Mol. Pharmacol. 48, 184.
Product Information
CAS number41443-28-1
ATP CompetitiveN
FormLight yellow powder
Hill FormulaC₉H₅N₃O₂
Chemical formulaC₉H₅N₃O₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target(NO)-sensitive guanylyl cyclase
Primary Target IC<sub>50</sub>20 nM against nitric oxide (NO)-sensitive guanylyl cyclase
Purity≥98% by TLC and HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
495320-10MG 04055977273045

Documentation

ODQ - CAS 41443-28-1 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

ODQ - CAS 41443-28-1 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
495320

Riferimenti bibliografici

Panoramica delle referenze
Wang, D., et al. 1998. J. Biol. Chem. 273, 33027.
Southam, E., et al. 1996. Br. J. Pharmacol. 119, 527.
Brunner, F., et al. 1995. FEBS Lett. 376, 262.
Garthwaite, J., et al. 1995. Mol. Pharmacol. 48, 184.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-August-2008 RFH
Synonyms1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
DescriptionA potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC50 = 20 nM). In incubated cerebellum slices, ODQ reversibly inhibits the NO-dependent cGMP response to glutamate receptor agonists without affecting NOS activity. It does not chemically inactivate NO; however, it does inhibit cGMP generation in response to NO donors. ODQ fails to inhibit NO-mediated macrophage toxicity, a phenomenon unrelated to cGMP, nor does it affect the activity of particulate guanylyl cyclase or adenylyl cyclase.
FormLight yellow powder
CAS number41443-28-1
Chemical formulaC₉H₅N₃O₂
Structure formulaStructure formula
Purity≥98% by TLC and HPLC
SolubilityDMSO (25 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesWang, D., et al. 1998. J. Biol. Chem. 273, 33027.
Southam, E., et al. 1996. Br. J. Pharmacol. 119, 527.
Brunner, F., et al. 1995. FEBS Lett. 376, 262.
Garthwaite, J., et al. 1995. Mol. Pharmacol. 48, 184.