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573108 STAT5 Inhibitor - CAS 285986-31-4 - Calbiochem

573108
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Panoramica

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Tabella delle specifiche principali

Empirical FormulaCAS #
C₁₆H₁₁N₃O₃ 285986-31-4

Products

Numero di catalogoConfezionamento Qtà/conf
573108-10MG Fiala di plastica 10 mg
Description
OverviewA cell-permeable nonpeptidic nicotinoyl hydrazone compound that selectively targets the SH2 domain of STAT5 (IC50 = 47 µM against STAT5b SH2 domain EPO peptide binding activity), while exhibiting much less effect towards the SH2 domain of STAT1, STAT3, or Lck (IC50 >500 µM). Shown to block STAT5/STAT5 DNA binding activity in K562 nuclear extract and inhibit IFN-α-stimulated STAT5, but not STAT1 or STAT3, tyrosine phosphorylation in Daudi cells.
Catalogue Number573108
Brand Family Calbiochem®
SynonymsNʹ-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
References
ReferencesMuller, J., et al. 2008. ChemBioChem 9, 723.
Product Information
CAS number285986-31-4
FormWhite solid
Hill FormulaC₁₆H₁₁N₃O₃
Chemical formulaC₁₆H₁₁N₃O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationSTAT5 Inhibitor, CAS 285986-31-4, is a cell-permeable compound that selectively targets the SH2 domain of STAT5 (IC50 = 47 µM against STAT5b SH2 domain EPO peptide binding activity).
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

STAT5 Inhibitor - CAS 285986-31-4 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

STAT5 Inhibitor - CAS 285986-31-4 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
573108

Riferimenti bibliografici

Panoramica delle referenze
Muller, J., et al. 2008. ChemBioChem 9, 723.

Informazioni tecniche

Titolo
JAK/STAT Signaling Research Focus
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-May-2011 RFH
SynonymsNʹ-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
DescriptionA cell-permeable nonpeptidic nicotinoyl hydrazone compound that selectively targets the SH2 domain of STAT5 (IC50 = 47 µM against STAT5b SH2 domain EPO peptide binding activity), while exhibiting much less effect towards the SH2 domain of STAT1, STAT3, or Lck (IC50 >500 µM). Shown to block STAT5/STAT5 DNA binding activity in K562 nuclear extract and inhibit IFN-α-stimulated STAT5, but not STAT1 or STAT3, tyrosine phosphorylation in Daudi cells.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number285986-31-4
Chemical formulaC₁₆H₁₁N₃O₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (25 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesMuller, J., et al. 2008. ChemBioChem 9, 723.