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448105 c-Met Kinase Inhibitor III - Calbiochem

448105
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₂₁H₁₇Cl₂FN₂O₂

Products

Numero di catalogoConfezionamento Qtà/conf
448105-2MG 2 mg
Description
OverviewA 6-Benzyloxyquinoline derivative which acts as an ATP-competitive inhibitor against c-Met (IC50 = 9.3 nM), with more than 20 fold selectivity against a panel of 19 receptor tyrosine kinases and 8 serine/threonine kinases, in enzymatic assays. Also exhibits MKN45 cell growth inhibition (IC50 = 93 nM) and displays HDG-dependent anti-proliferative activity (IC50 = 300 nM) in HUVEC cultures, in vitro.
Catalogue Number448105
Brand Family Calbiochem®
Synonyms2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)cyclopropanecarboxamide
References
ReferencesNishii, H., et al. 2009. Bioorg. Med. Chem. Lett. 20, 1405.
Product Information
FormWhite solid
Hill FormulaC₂₁H₁₇Cl₂FN₂O₂
Chemical formulaC₂₁H₁₇Cl₂FN₂O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HLPC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

c-Met Kinase Inhibitor III - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

c-Met Kinase Inhibitor III - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
448105

Riferimenti bibliografici

Panoramica delle referenze
Nishii, H., et al. 2009. Bioorg. Med. Chem. Lett. 20, 1405.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-February-2011 RFH
Synonyms2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)cyclopropanecarboxamide
DescriptionA 6-Benzyloxyquinoline derivative which acts as an ATP-competitive inhibitor against c-Met (IC50 = 9.3 nM), with more than 20 fold selectivity against a panel of 19 receptor tyrosine kinases and 8 serine/threonine kinases, in enzymatic assays. Also exhibits MKN45 cell growth inhibition (IC50 = 93 nM) and displays HDG-dependent anti-proliferative activity (IC50 = 300 nM) in HUVEC cultures, in vitro.
FormWhite solid
Chemical formulaC₂₁H₁₇Cl₂FN₂O₂
Structure formulaStructure formula
Purity≥95% by HLPC
SolubilityDMSO (50 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesNishii, H., et al. 2009. Bioorg. Med. Chem. Lett. 20, 1405.