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475965 c-Myc Inhibitor III, Mycro2 - Calbiochem

475965
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₁₇H₁₁F₃N₄OS₂

Products

Numero di catalogoConfezionamento Qtà/conf
475965-10MG Bottiglia di vetro 10 mg
Description
OverviewA cell-permeable pyrazolopyrimidine-carboxamide that selectively inhibits c-Myc-Max dimer DNA binding activity (IC50 = 23 µM) by preventing c-Myc-Max heterodimer formation, while affecting Max, Jun, C/EBPα homodimers, or Jun-Fos heterodimer DNA binding only at much higher concentrations (IC50 = ≥54 µM). Shown to selectively inhibit c-Myc-Max-dependent transcription (by 77% against E-Box promoter-driven reporter transcription at 10 µM), cancer proliferation, and anchorage-independent colony formation (Effective conc. 10-20 µM).
Catalogue Number475965
Brand Family Calbiochem®
Synonyms5-(Thiophen-2-yl)-N-(thiophen-2-ylmethyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
References
ReferencesKiessling, A., et al. 2006. Chem. Biol. 13, 745.
Product Information
FormYellow solid
Hill FormulaC₁₇H₁₁F₃N₄OS₂
Chemical formulaC₁₇H₁₁F₃N₄OS₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetα-helical dimerization motifs of c-Myc/Max factors
Primary Target IC<sub>50</sub>IC₅₀ = 23 and 54 µM for c-Myc/Max and Max/Max dimerization
Secondary targetα-helical dimerization motifs of Max/Max factors
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

c-Myc Inhibitor III, Mycro2 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

c-Myc Inhibitor III, Mycro2 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
475965

Riferimenti bibliografici

Panoramica delle referenze
Kiessling, A., et al. 2006. Chem. Biol. 13, 745.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision29-September-2012 JSW
Synonyms5-(Thiophen-2-yl)-N-(thiophen-2-ylmethyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
DescriptionA cell-permeable pyrazolopyrimidine-carboxamide that selectively inhibits c-Myc-Max dimer DNA binding activity (IC50 = 23 µM) by preventing c-Myc-Max heterodimer formation, while affecting Max, Jun, C/EBPα homodimers, or Jun-Fos heterodimer DNA binding only at much higher concentrations (IC50 = 54 µM for Max-Max dimer and IC50 > >54 µM for the rest). Shown to selectively inhibit c-Myc-Max-dependent transcription (by 77%, 31%, and 19%, respectively, against E-Box, AP-1, and SRE promoter-driven reporter transcription with 10 µM inhibitior), anchorage-independent colony formation (By 40% and 2%, respectively, against c-Myc or v-Src transformed Rat1a cells with 15 µM inhibitor) and proliferation (Effective conc. 10-20 µM in Raji, MCF-7, and U2OS cultures), but not c-Myc-independent proliferation of PC-12 cells (by <10% at 20 µM).
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₇H₁₁F₃N₄OS₂
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (100 mg/ml; clear, yellow solution)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesKiessling, A., et al. 2006. Chem. Biol. 13, 745.