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475958 c-Raf Inhibitor - Calbiochem

475958
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₂₃H₁₉F₃N₈O

Products

Numero di catalogoConfezionamento Qtà/conf
475958-20MG Bottiglia di vetro 20 mg
Description
OverviewA cell-permeable pyrazoloimidazole phenyl urea derivative that acts as a selective type II inhibitor of c-Raf. It shows an IC50 value of 50 nM in an enzymatic assay, and comparable anti-proliferative activities to sorafenib against A375P (GI 50 = 2.68 µM) and WM3629 (GI50 = 0.86 µM) human melanoma cell lines. When screening against a panel of 30 different kinases at a concentration of 10 µM, it exerts an inhibitory activity of 96% on c-Raf, but below 50% for most of the other kinases.
Catalogue Number475958
Brand Family Calbiochem®
Synonyms1-(3-(1,4-dihydroimidazo[4,5-c]pyrazol-5-yl)-4-methylphenyl)-3-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)urea, c-Raf Inhibitor
References
ReferencesYu, H., et al. 2010. Bioorg. Med. Chem. Lett. 20, 3805.
Product Information
FormOff white solid
Hill FormulaC₂₃H₁₉F₃N₈O
Chemical formulaC₂₃H₁₉F₃N₈O
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

c-Raf Inhibitor - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

c-Raf Inhibitor - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
475958

Riferimenti bibliografici

Panoramica delle referenze
Yu, H., et al. 2010. Bioorg. Med. Chem. Lett. 20, 3805.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-June-2011 RFH
Synonyms1-(3-(1,4-dihydroimidazo[4,5-c]pyrazol-5-yl)-4-methylphenyl)-3-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)urea, c-Raf Inhibitor
DescriptionA cell-permeable pyrazoloimidazole phenyl urea derivative that acts as a selective type II inhibitor of c-Raf. It shows an IC50 value of 50 nM in an enzymatic assay, and comparable anti-proliferative activities to sorafenib against A375P (GI 50 = 2.68 µM) and WM3629 (GI50 = 0.86 µM) human melanoma cell lines. When screening against a panel of 30 different kinases at a concentration of 10 µM, it exerts an inhibitory activity of 96% on c-Raf, but below 50% for most of the other kinases.
FormOff white solid
Chemical formulaC₂₃H₁₉F₃N₈O
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesYu, H., et al. 2010. Bioorg. Med. Chem. Lett. 20, 3805.