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344036 cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem

344036
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical FormulaCAS #
C₂₀H₂₂N₄O₃ 870483-87-7

Products

Numero di catalogoConfezionamento Qtà/conf
344036-1MG Fiala di plastica 1 mg
Description
OverviewA cell-permeable diaminopyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of cFMS kinase activity (IC50 = 30 nM) with minimal inhibition towards a panel of 26 other kinases (IC50 >5 µM). Shown to selectively inhibit cFMS-mediated cellular functions in vitro as well as CSF-1-dependent tumor growth in vivo. A 10 mM (1 mg/273 µl) solution of cFMS Receptor Tyrosine Kinase Inhibitor (Cat. No. 344041) in DMSO is also available.
Catalogue Number344036
Brand Family Calbiochem®
Synonyms5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)-pyrimidine-2,4-diamine, CSF-1 Receptor Inhibitor, GW2580
References
ReferencesConway, J.G., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 16078.
Product Information
CAS number870483-87-7
ATP CompetitiveY
FormOff-white solid
Hill FormulaC₂₀H₂₂N₄O₃
Chemical formulaC₂₀H₂₂N₄O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCFMS
Primary Target IC<sub>50</sub>30 nM against cFMS kinase activity
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
344036

Riferimenti bibliografici

Panoramica delle referenze
Conway, J.G., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 16078.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-June-2010 JSW
Synonyms5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)-pyrimidine-2,4-diamine, CSF-1 Receptor Inhibitor, GW2580
DescriptionA cell-permeable diaminopyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of cFMS kinase activity (IC50 = 30 nM) with minimal inhibition towards a panel of 26 other kinases (IC50 >5 µM). Shown to selectively inhibit cFMS-mediated cellular functions in vitro as well as CSF-1-dependent tumor growth in vivo.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number870483-87-7
Chemical formulaC₂₀H₂₂N₄O₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (25 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesConway, J.G., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 16078.