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344300 sFRP-1 Inhibitor - CAS 915754-88-0 - Calbiochem

344300
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
915754-88-0C₁₉H₂₆N₂O₄S₂

Products

Numero di catalogoConfezionamento Qtà/conf
344300-5MG Bottiglia di vetro 5 mg
Description
OverviewA diphenylsulfone-sulfonamide compound that counteracts the antagonizing effect of SARP-2/sFRP-1 (secreted frizzled related protein-1) against Wnt-3/frizzled interaction and Wnt-3/frizzled-stimulated cellular functions (EC50 = 1.27 µM in a U2OS-based reporter assay) with a reported aqueous solubility of 26 µg/ml at pH 7.4 and in vitro half-lives of 12 and 26.7 min using rat and human microsomes, respectively.
Catalogue Number344300
Brand Family Calbiochem®
SynonymsN-(3-(Dimethylamino)propyl)-2-ethyl-5-(phenylsulfonyl)benzenesulfonamide, Secreted Frizzled Related Protein-1 Inhibitor, Wnt Pathway Activator IV
References
ReferencesGopalsamy, A., et al. 2008. J. Med. Chem. 51, 7670.
Product Information
CAS number915754-88-0
FormClear oil
Hill FormulaC₁₉H₂₆N₂O₄S₂
Chemical formulaC₁₉H₂₆N₂O₄S₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

sFRP-1 Inhibitor - CAS 915754-88-0 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

sFRP-1 Inhibitor - CAS 915754-88-0 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
344300

Riferimenti bibliografici

Panoramica delle referenze
Gopalsamy, A., et al. 2008. J. Med. Chem. 51, 7670.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-April-2011 RFH
SynonymsN-(3-(Dimethylamino)propyl)-2-ethyl-5-(phenylsulfonyl)benzenesulfonamide, Secreted Frizzled Related Protein-1 Inhibitor, Wnt Pathway Activator IV
DescriptionA diphenylsulfone-sulfonamide compound that counteracts the antagonizing effect of SARP-2/sFRP-1 (secreted frizzled related protein-1) against Wnt-3/frizzled interaction and Wnt-3/frizzled-stimulated cellular functions (EC50 = 1.27 µM in a U2OS-based reporter assay) with a reported aqueous solubility of 26 µg/ml at pH 7.4 and in vitro half-lives of 12 and 26.7 min using rat and human microsomes, respectively.
FormClear oil
Intert gas (Yes/No) Packaged under inert gas
CAS number915754-88-0
Chemical formulaC₁₉H₂₆N₂O₄S₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesGopalsamy, A., et al. 2008. J. Med. Chem. 51, 7670.