Chiral Stationary Phases for HPLC 

Chiral chromatography has become a necessary tool - not only for the analytical determination of enantiomeric purity, but also for the isolation of pure enantiomers. Its importance has particularly grown in the pharmaceutical, chemical, and agricultural industries. The chromatographic enantiomer separation by chiral stationary phase is an efficient and rapid method used in the control of chiral pharmaceuticals or flavor ingredients. The characteristics that make compounds chiral can produce critically different pharmacological effects in biological systems. As a result, the demand for stereoselective separation techniques and analytical assays to evaluate the enantiomeric purity of chiral compounds has increased.

To answer these needs, Merck offers ChiraDex® HPLC top quality columns for enantiomer analysis. Our ChiraDex® stationary phase is a versatile HPLC column characterized by broad enantioselectivity and can be used for the separation of enantiomers of numerous different classes of substances. ChiraDex® is based on beta-cyclodextrin covalently linked to spherical particles of silica, and is well suited for the chiral separation of hydrocarbons, steroids, phenol esters and derivatives, aromatic amines, and heterocycles with a 5-membered ring to 7-membered ring. Simply composed RP-eluents can be used in most separations.