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5.05316

PHA-543,613

Name: PHA-543,613
Brand: MM

Synonym(s):

PHA-543,613, N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, Alpha 7 Nicotinic Acetylcholine Receptor (α7 nAChR) Agonist, PHA-543613

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₇N₃O₂

CAS Number:

478149-53-0

Molecular Weight:

271.31

UNSPSC Code:

12352200

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

OK to freeze, protect from light

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Properties

assay

≥98% (HPLC)

Quality Segment

100

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 20 mg/mL

storage temp.

2-8°C

InChI

1S/C15H17N3O2/c19-15(12-7-11-3-6-20-14(11)8-16-12)17-13-9-18-4-1-10(13)2-5-18/h3,6-8,10,13H,1-2,4-5,9H2,(H,17,19)/t13-/m0/s1

InChI key

IPKZCLGGYKRDES-ZDUSSCGKSA-N

Description

General description

A potent agonist highly selective for α7 nicotinic acetylcholine receptor (α7 nAChR). Bioavaible admitted orally. Widely used in studies of the functional roles of α7 nAChR in learning and memory, sensory gating, and cognitive functions as well as Schizophrenia and Alzheimer′s disease.

Biochem/physiol Actions

Primary Target
α7 nAChR

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Mazurov, A., et al., 2011. J. Med. Chem.54, 7943.
Wishka, G., et al., 2006. J. Med. Chem.49, 4425.
Faghih, R., et al., 2008. J. Med. Chem.51, 701.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c