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5.05878

PD 168077 Maleate

Name: PD 168077 Maleate
Brand: MM

Synonym(s):

PD 168077 Maleate, D₄ Dopamine Receptor Agonist, PD 168077 Maleate, PD168077, PD-168077

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₂N₄O · xC₄H₄O₄

CAS Number:

630117-19-0

Molecular Weight:

334.41 (free base basis)

MDL number:

MFCD01321067

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Properties

assay

≥98% (HPLC)

Quality Segment

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 100 mM

storage temp.

−20°C

SMILES string

N2(CCN(CC2)c3c(cccc3)C#N)CNC(=O)c1cc(ccc1)C.OC(=O)\C=C/C(=O)O

InChI

1S/C20H22N4O.C4H4O4/c1-16-5-4-7-17(13-16)20(25)22-15-23-9-11-24(12-10-23)19-8-3-2-6-18(19)14-21;5-3(6)1-2-4(7)8/h2-8,13H,9-12,15H2,1H3,(H,22,25);1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

NAEUGRPISCANHO-BTJKTKAUSA-N

Description

General description

A selective D₄ dopamine receptor agonist (K_i = 8.7 nM, EC₅₀ = 8.3 nM). Suitable for central and peripheral delivery. Used in studies of penile erection, learning and memory. Exibits some binding affinity towards human D₂ and D₃ Receptors (K_i = 2.8 µM).

Biochem/physiol Actions

Primary Target
D₄

Reversible: yes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Melis, M. R. et al. 2005. Neurosci. Lett.379, 59.
Bernaerts, P. et al. 2003. Behav. Brain Res.142, 41.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c