5.05982
(-)-Quinpirole Hydrochloride
Synonym(s):
(-)-Quinpirole Hydrochloride, Dopamine D2 Receptor Agonist, Quinpirole, Quinpirole, LY-171,555, LY 171555
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About This Item
Empirical Formula (Hill Notation):
C13H21N3 · xHCl
CAS Number:
Molecular Weight:
219.33 (free base basis)
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light
assay
≥98% (HPLC)
Quality Segment
form
powder
potency
4.8 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
water: 7.3 mg/mL
storage temp.
−20°C
InChI
1S/C13H21N3.ClH/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12;/h9-10,13H,2-8H2,1H3,(H,14,15);1H/t10-,13-;/m1./s1
InChI key
HJHVRVJTYPKTHX-HTMVYDOJSA-N
General description
A potent, selective dopamine D2 receptor agonist with a Ki value of 4.8 nM. Some D3(Ki = 24 nM) and D4 (Ki = 30 nM) receptor agonistic action has also been reported. In rat striatum studies in vitro, application of quinpriole inhibited single pulse dopamine overflow in a concentration-dependent manner (IC50 = 32.5 nM).
Other Notes
OʹNeill, C. et al. 2009. J. Neurochem.108, 545.
Malmberg, A. and Mohell, N. 1995. J. Pharmacol. Exp. Ther.274, 790.
Seeman, P. and Schaus, J. M. 1991. Eur. J. Pharmacol.203, 105.
Malmberg, A. and Mohell, N. 1995. J. Pharmacol. Exp. Ther.274, 790.
Seeman, P. and Schaus, J. M. 1991. Eur. J. Pharmacol.203, 105.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
Certificates of Analysis (COA)
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