5.08052
iMDK
≥98% (HPLC), solid, midkine inhibitor, Calbiochem®
Synonym(s):
Midkine Inhibitor, iMDK, 3-(2-(4-Fluorobenzyl)imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one, 3-(2-(4-Fluorobenzyl)imidazo[2,1-b][1,3]thiazol-6-yl)-2H-chromen-2-one, MDK Expression Inhibitor
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About This Item
Empirical Formula (Hill Notation):
C21H13FN2O2S
CAS Number:
Molecular Weight:
376.40
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Product Name
Midkine Inhibitor, iMDK,
assay
≥98% (HPLC)
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 5 mg/mL
storage temp.
2-8°C
SMILES string
C1=CC=C2C(=C1)C=C(C(=O)O2)C3=CN4C=C(SC4=N3)CC5=CC=C(C=C5)F
InChI key
IWFKQTWYILKFGE-UHFFFAOYSA-N
General description
The midkine inhibitor, iMDK, demonstrates strong antiproliferative and antitumor effects both in vitro and in vivo in non-small-cell lung cancer. It also induces apoptosis of primary effusion lymphoma through G2/M cell cycle arrest.
Application
Midkine Inhibitor, iMDK may be used to study its anti-cancer activity on primary effusion lymphoma (PEL) in vitro.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Midkine
Midkine
Reversible: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Hao, H., et al. 2013. PLoS ONE8, e71093.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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