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PC150 Anti-β-Amyloid (1-42) Rabbit pAb

This Anti-β-Amyloid (1-42) Rabbit pAb is validated for use in Dot Blot, ELISA, Radioimmunoassay for the detection of β-Amyloid (1-42).

Anti-β-Amyloid (1-42) Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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PC150
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Overview

Replacement Information

Key Spec Table

Species ReactivityHostAntibody Type
HRbPolyclonal Antibody

Pricing & Availability

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PC150-25UGCN
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      		 Plastic ampoule 25 μg
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      Description
      OverviewRecognizes specifically β-amyloid peptide (1-42). Does not cross-react with β-amyloid peptide (1-40) or β-amyloid peptide (1-43).
    • Antibody Target Gene Symbol: APP
    • Target Synonym: AAA, AD1, Adap, AL024401, Amyloid precursor, Amyloidogenic glycoprotein, APP isoform 1, APPI, appican, CTFgamma, CVAP, E030013M08RIK, Nexin II, P3, PN2, PreA4, PROTEASE NEXIN2
    • Entrez Gene Name: amyloid beta (A4) precursor protein
    • Hu Entrez ID: 351 (Related Antibodies: 171610, PC729,PC152, PC151, PC149, NE1012,171609, 171608, 171607, 171606, 171605, 171604, 171603, 171598, 171537)
    • Mu Entrez ID: 11820
    • Rat Entrez ID: 54226
      		•
      Catalogue NumberPC150
      Brand Family Calbiochem®
      References
      ReferencesSavage, M.J., et al. 1998. J. Neurosci. 15, 1743.
      Borchelt, D.R., et al. 1997. Neuron 19, 939.
      Citron, M., et al. 1997. Nature Med. 3, 67.
      Hardy, J. 1997. Trends in Neurosci. 20, 154.
      Solomon, B., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 4109.
      Duff, K., et al. 1996. Nature 383, 710.
      Iwatsubo, T., et al. 1994. Neuron 13, 45.
      Suzuki, N., et al. 1994. Science 264, 133.
      Product Information
      FormLiquid
      FormulationIn phosphate buffer, pH 7.4.
      PreservativeNone
      Quality LevelMQ100
      Applications
      Key Applications Dot Blot
      Enzyme-Linked Immunosorbent Assay
      Radioimmunoassay
      Application NotesDot Blot (0.1-0.5 µg/ml)
      ELISA (0.1-0.5 µg/ml)
      Radioimmunoassay (0.5 µg/ml)
      Application CommentsThis antibody is specific for β-amyloid peptide [1-42] and shows no reactivity to β-amyloid peptide [1-40] or β-amyloid peptide [1-43]. This antibody is recommended for use in the quantitative determination of β-amyloid peptide [1-42]. The sensitivity level for sandwich ELISA is 15-25 pg. Antibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogena synthetic peptide corresponding to amino acids from a C-terminal fragment of human β-amyloid peptide (1-42)
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      PC150-25UGCN 04055977209471

      Documentation

      Anti-β-Amyloid (1-42) Rabbit pAb SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-β-Amyloid (1-42) Rabbit pAb Certificates of Analysis

      TitleLot Number
      PC150

      References

      Reference overview
      Savage, M.J., et al. 1998. J. Neurosci. 15, 1743.
      Borchelt, D.R., et al. 1997. Neuron 19, 939.
      Citron, M., et al. 1997. Nature Med. 3, 67.
      Hardy, J. 1997. Trends in Neurosci. 20, 154.
      Solomon, B., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 4109.
      Duff, K., et al. 1996. Nature 383, 710.
      Iwatsubo, T., et al. 1994. Neuron 13, 45.
      Suzuki, N., et al. 1994. Science 264, 133.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-October-2007 RFH
      ApplicationDot Blot (0.1-0.5 µg/ml)
      ELISA (0.1-0.5 µg/ml)
      Radioimmunoassay (0.5 µg/ml)
      DescriptionRabbit polyclonal antibody adsorbed against Aβ1-40 and Aβ1-43, followed by immunoaffinity purification. Recognizes specifically β-amyloid peptide (1-42).
      BackgroundA number of mutations, identified in the gene encoding the β-amyloid precursor protein (βAPP), have been linked to early-onset Familial Alzheimer's Disease. Mutations in the genes encoding presenilin 1 and presenilin 2 have also been shown to alter the processing of βAPP, resulting in increased extracellular concentration of β-amyloid peptide Aβ1-42(43) relative to Aβ1-40. Biophysical and biochemical experiments suggest that Aβ1-42(43) may serve as a catalyst for the aggregation and deposition of Aβ leading to neurotoxic effects associated with senile plaque formation. Furthermore, antibodies recognizing Aβ1-42 revealed that the long form of the peptide is increased in presenilin and βAPP mutants while other studies have used Aβ specific antibodies to prevent the in vitro fibrillar aggregation of Aβ.
      HostRabbit
      Immunogen speciesHuman
      Immunogena synthetic peptide corresponding to amino acids from a C-terminal fragment of human β-amyloid peptide (1-42)
      IsotypeIgG
      Specieshuman
      FormLiquid
      FormulationIn phosphate buffer, pH 7.4.
      Concentration Label Please refer to vial label for lot-specific concentration
      PreservativeNone
      CommentsThis antibody is specific for β-amyloid peptide [1-42] and shows no reactivity to β-amyloid peptide [1-40] or β-amyloid peptide [1-43]. This antibody is recommended for use in the quantitative determination of β-amyloid peptide [1-42]. The sensitivity level for sandwich ELISA is 15-25 pg. Antibody should be titrated for optimal results in individual systems.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesSavage, M.J., et al. 1998. J. Neurosci. 15, 1743.
      Borchelt, D.R., et al. 1997. Neuron 19, 939.
      Citron, M., et al. 1997. Nature Med. 3, 67.
      Hardy, J. 1997. Trends in Neurosci. 20, 154.
      Solomon, B., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 4109.
      Duff, K., et al. 1996. Nature 383, 710.
      Iwatsubo, T., et al. 1994. Neuron 13, 45.
      Suzuki, N., et al. 1994. Science 264, 133.