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MABF376

Anti-CD11c Antibody (mouse), PE-Cy7, clone N418

clone N418, 0.2 mg/mL, from hamster(Armenian)

Synonym(s):

Integrin alpha-Xl, CD11 antigen-like family member C, Leukocyte adhesion glycoprotein p150,95 alpha chain, Leukocyte adhesion receptor p150,95, CD11c

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.44
eCl@ss:
32160702
Conjugate:
PE-Cy7
Clone:
N418, monoclonal
Application:
FACS, IF, IHC, IP
Citations:
-
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biological source

hamster (Armenian)

Quality Segment

100

conjugate

PE-Cy7

antibody form

purified antibody

antibody product type

primary antibodies

clone

N418, monoclonal

species reactivity

mouse

concentration

0.2 mg/mL

technique(s)

flow cytometry: suitable, immunofluorescence: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable

isotype

IgG

UniProt accession no.

Q9QXH4

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Itgax(16411)

General description

The N418 antibody reacts with mouse CD11c, also known as integrin alpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor complex known as CR4 which can bind and induce signaling throµgh ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The N418 antibody is widely used as a marker for CD11c expression on dendritic cells (DC), often in parallel with markers for CD11b, for identification of developmental stages and mature subsets of this cell type. CD11c is prominently expressed on tissue macrophages, and is also detected on some types of activated T cells and intestinal intraepithelial lymphocytes (IEL).
This armenian hamster monoclonal antibody Anti-CD11c (mouse), PE-Cy7, clone N418 validated for use in IP, IHC, Immunofluorescence & Flow Cytometry for the detection of CD11c.

Analysis Note

The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 1 µg of this antibody detected CD11c in one million C57Bl/6 splenocytes.

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

MABF376:

jan

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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