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ABE1082 Anti-JARID1C Antibody

Anti-JARID1C Antibody detects level of JARID1C & has been published & validated for use in JARID1C.

Anti-JARID1C Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Chromatin Biology Gene Symbol: KDM5C UniProt Number: P41229
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ABE1082
200 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE1082
      DescriptionAnti-JARID1C Antibody
      Alternate Names
      • Lysine-specific demethylase 5C
      • Histone demethylase JARID1C
      • Jumonji/ARID domain-containing protein 1C
      • Protein SmcX
      • Protein Xe169
      Background InformationJARID1C, also known as Jumonji/ARID domain-containing protein 1C, Protein SmcX, or Protein Xe169, and encoded by the gene KDM5C/DXS1272E/JARID1/SMCX/XE169, a histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. JARID1C demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. JARID1C does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Additionally, JARID1C participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. JARID1C is localized to the nucleus. Defects in JARID1C are associated with Mental retardation, X-linked, syndromic, Claes-Jensen type (MRXSCJ) disorder. MRXSCJ patients have below average general intellectual functioning associated with impairments in adaptive behavior during development, and suffer mental retardation, progressive spastic paraplegia, seizures, and facial dysmorphism.
      References
      Product Information
      FormatPurified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-JARID1C Antibody detects level of JARID1C & has been published & validated for use in JARID1C.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenLinear peptide corresponding to human JARID1C.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KDM5C
      Purification MethodProtein A Purfied
      UniProt Number
      Molecular Weight~175 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HEK293 cell lysate.

      Western Blotting Analysis: 2 µg/mL of this antibody detected JARID1C in 10 µg of HEK293 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABE1082 04053252939570

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies