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ABE364 Anti-Tet2 Antibody

Anti-Tet2 detects levels of Tet2 proteins & has been published & validated for use in WB, IHC & ICC.

Anti-Tet2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Chromatin Biology Gene Symbol: TET2 UniProt Number: Q6N021
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ABE364
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, MWB, IH(P), ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE364
      DescriptionAnti-Tet2 Antibody
      Alternate Names
      • Methylcytosine dioxygenase TET2
      Background InformationMethylcytosine dioxygenase TET2 catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). The function of 5-hydroxymethylcytosine is currently unclear but it may influence chromatin structure, or act as an intermediate component in cytosine demethylation. TET2 is frequently mutated in myeloproliferative disorders (MPD) or myeloproliferative neoplasms (MPN), and systemic mastocytosis. TET2 disorders also cause polycythemia vera (PV) and myelodysplastic syndrome (MDS).
      References
      Product Information
      FormatAffinity Purified
      Control
      • Mouse Embryonic Stem cells
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Tet2 detects levels of Tet2 proteins & has been published & validated for use in WB, IHC & ICC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      • Immunocytochemistry
      Application NotesImmunohistochemistry Analysis: A 1:4,000 dilution from a representative lot detected Tet2 in rat medulla tissue.

      Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected Tet2 in human H9 Embryonic Stem cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Tet2.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Rat
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TET2
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~140 kDa observed. Three isoforms at 223 kDa (isoform 1), 130 kDa (isoform 2), and 133 kDa (isoform 3) are known to exist. This antibody should recognize all three isoforms based on sequence homology. An uncharacterized band may be observed at ~36 kDa in some cell lysates. (Note: Isoforms 2 and 3 may observed at low concentrations, while isoform 1 may be detected at higher concentrations in certain cell lysates.)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse Embryonic Stem cells.

      Western Blotting Analysis: 1 µg/mL of this antibody detected Tet2 in 10 µg of mouse Embryonic Stem cells (Note: Isoforms 2 and 3 may observed at low concentrations or longer exposure times, while isoform 1 may be detected at higher concentrations or longer exposure times in certain cell lysates.).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABE364 04053252859533

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies