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MAB11004

Anti-hnRNP Q Antibody, clone 7A11.2

clone 7A11.2, from mouse

Synonym(s):

heterogeneous nuclear ribonucleoprotein Q-like, Synaptotagmin-binding, cytoplasmic RNA-interacting protein, Glycine- and tyrosine-rich RNA-binding protein, GRY-RBP, NS1-associated protein 1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
7A11.2, monoclonal
Application:
ICC, WB
Citations:
4
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biological source

mouse

Quality Segment

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

7A11.2, monoclonal

species reactivity

mouse, rat, human

technique(s)

immunocytochemistry: suitable, western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_001153145

UniProt accession no.

O60506

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... SYNCRIP(10492)

General description

Heterogeneous nuclear ribonucleoprotein Q, commonly refered to as hnRNP Q, can be found as three different isoforms derived from alternative splicing of a single gene. This RNA binding protein is implicated in control of mRNA precursor splicing for the survival of motor neurons (SMN) protein. Loss-of-function mutations of SMN are linked to spinal muscular atrophy (SMA) a common neurodegenerative disease. It has been shown that hnRNP Q proteins interact with SMN, and this is interacton is required for efficient pre-mRNA splicing in vitro. Current data suggests that hnRNP Q is a splicing modulator of SMN.
~59 observed. Mulitple isoforms may be observed in some lysates.

Immunogen

Full length recombinant protein corresponding to human hnRNPQ.

Application

Anti-hnRNP Q Antibody, clone 7A11.2 is a Mouse Monoclonal Antibody for detection of hnRNP Q also known as heterogeneous nuclear ribonucleoprotein Q-like & has been validated in WB, ICC.
Western Blot Analysis: 1 µg/mL from a representative lot detected hnRNP Q on 10 µg of PC-12 and HEK293 cell lysate.

Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected hnRNP Q in NIH/3T3, A431, and HeLa cells.

Physical form

Format: Purified

Analysis Note

Evaluated by Western Blot in NIH/3T3 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected hnRNP Q on 10 µg of NIH/3T3 cell lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

MAB11004:

jan

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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