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235423 Caspase-3 Inhibitor I, Cell-Permeable - Calbiochem

The Caspase-3 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

Caspase-3 Inhibitor I, Cell-Permeable - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: CPP32/Apopain Inhibitor, Cell-permeable, Cell-permeable, DEVD-CHO

Primary Target: caspase-3
View This Product on Sigma-Aldrich
235423
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₉₄H₁₅₈N₂₀O₂₇

Pricing & Availability

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235423-1MGCN
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      		 Plastic ampoule 1 mg
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      Description
      OverviewA cell-permeable inhibitor of caspase-3, as well as caspase-6, caspase-7, caspase-8, and caspase-10. The C-terminal DEVD-CHO sequence of this peptide is a highly specific, potent, and reversible inhibitor of caspase-3 (Ki < 1 nM) that has also been shown to strongly inhibit PARP cleavage in cultured human osteosarcoma cell extracts (IC50 = 200 pM). The N-terminal sequence (amino acid residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide. A 5 mM (1 mg/100 µl) solution of Caspase-3 Inhibitor I, Cell-permeable (Cat. No. 235427) in DMSO is also available.
      Catalogue Number235423
      Brand Family Calbiochem®
      SynonymsCPP32/Apopain Inhibitor, Cell-permeable, Cell-permeable, DEVD-CHO
      References
      ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Lin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305.
      Nicholson, D.W. 1996. Nature Biotechnol. 14, 297.
      Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
      Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
      Nicholson, D.W., et al. 1995. Nature 376, 37.
      Tewari, M., et al. 1995. Cell 81, 801.
      Lazebnik, Y.A., et al. 1994. Nature 371, 346.
      Product Information
      ATP CompetitiveN
      FormLyophilized solid
      Hill FormulaC₉₄H₁₅₈N₂₀O₂₇
      Chemical formulaC₉₄H₁₅₈N₂₀O₂₇
      HS Code2933 99 99
      ReversibleY
      Sold on the basis of peptide contentY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcaspase-3
      Primary Target IC<sub>50</sub>200 pM for inhibiting PARP cleavage in cultured human osteosarcoma cell extracts
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide ContentY
      Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      235423-1MGCN 04055977217025

      Documentation

      Caspase-3 Inhibitor I, Cell-Permeable - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Caspase-3 Inhibitor I, Cell-Permeable - Calbiochem Certificates of Analysis

      TitleLot Number
      235423

      References

      Reference overview
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Lin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305.
      Nicholson, D.W. 1996. Nature Biotechnol. 14, 297.
      Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
      Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
      Nicholson, D.W., et al. 1995. Nature 376, 37.
      Tewari, M., et al. 1995. Cell 81, 801.
      Lazebnik, Y.A., et al. 1994. Nature 371, 346.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure

      Citations

      Title
    • Jurg Grunenfelder, et al. (2001) Upregulation of Bcl-2 through caspase-3 inhibition ameliorates ischemia/reperfusion injury in rat cardiac allografts. Circulation 104, I202-I206.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-February-2014 JSW
      SynonymsCPP32/Apopain Inhibitor, Cell-permeable, Cell-permeable, DEVD-CHO
      DescriptionA cell-permeable inhibitor of caspase-3. The C-terminal DEVD-CHO sequence of this peptide is a highly specific, potent and reversible inhibitor of caspase-3 (Ki <1 nM) that has also been shown to strongly inhibit PARP cleavage in cultured human osteosarcoma cell extracts (IC50 = 0.2 nM). The N-terminal sequence (residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide.
      FormLyophilized solid
      Chemical formulaC₉₄H₁₅₈N₂₀O₂₇
      Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Lin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305.
      Nicholson, D.W. 1996. Nature Biotechnol. 14, 297.
      Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
      Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
      Nicholson, D.W., et al. 1995. Nature 376, 37.
      Tewari, M., et al. 1995. Cell 81, 801.
      Lazebnik, Y.A., et al. 1994. Nature 371, 346.
      Citation
    • Jurg Grunenfelder, et al. (2001) Upregulation of Bcl-2 through caspase-3 inhibition ameliorates ischemia/reperfusion injury in rat cardiac allografts. Circulation 104, I202-I206.
      		•