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IL035 Interleukin-10 Protein, Recombinant rat

The recombinant rat Interleukin-10 protein, originally known as Cytokine Synthesis Inhibitory Factor (CSIF) is an 18.7 kDa protein of 160 amino acid residues that shares over 80% sequence homology with the Epstein-Barr Virus protein BCRFI.

Interleukin-10 Protein, Recombinant rat MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Cell Culture UniProt Number: P15248, P29456
IL035
10 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Key ApplicationsSpeciesPurity
      CULTRat Greater than 98% by SDS-PAGE and HPLC analysis
      Description
      Catalogue NumberIL035
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionInterleukin-10 Protein, Recombinant rat
      OverviewRecombinant Rat Interleukin-10 (IL-10), originally known as Cytokine Synthesis Inhibitory factor (CSIF), is an 18.7 kDa protein of 160 amino acid residues that shares over 80% sequence homology with the Epstein-Barr virus protein BCRFI.
      Alternate Names
      • IL-10
      References
      Product Information
      PresentationLyophilized from 5mM Tris, pH 7.2.
      Quality LevelMQ100
      Applications
      ApplicationThe recombinant rat Interleukin-10 protein, originally known as Cytokine Synthesis Inhibitory Factor (CSIF) is an 18.7 kDa protein of 160 amino acid residues that shares over 80% sequence homology with the Epstein-Barr Virus protein BCRFI.
      Key Applications
      • Cell Culture
      Biological Information
      PurityGreater than 98% by SDS-PAGE and HPLC analysis
      Specific ActivityThe ED(50) was determined by the dose-dependent inhibition of antigen-specific T-cell proliferation is <10 ng/mL.
      Entrez Gene SummaryThe protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness.
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P15248 # Supports IL-2 independent and IL-4 independent growth of helper T-cells.
      SIZE: 144 amino acids; 15909 Da
      SUBCELLULAR LOCATION: Secreted.
      SIMILARITY: SwissProt: P15248 ## Belongs to the IL-7/IL-9 family.
      Stem Cell Type
      • Hematopoietic Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe lyophilized protein is stable for a few weeks at room temperature, but best stored at -20ºC. We recommend a quick spin followed by reconstitution in 5 mM Tris, pH7.2, to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers and stored at 4ºC for 1 week or -20ºC for future use. Reconstituted IL-10 should be stored in working aliquots at -20°C.
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      IL035 04053252408731

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      Product Families

      Cytokines and Growth Factors

      EMD Millipore offers a comprehensive range of highly purified bioactive cytokines and growth factors for use in human, mouse, and rat cell culture, stem cell differentiation and ELISA studies.
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      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors