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20-114 PKA Inhibitor Cocktail

PKA Inhibitor Cocktail MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Kinase Assay
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20-114
1 mL  
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      Overview

      Replacement Information

      Key Spec Table

      Key Applications
      KA
      Description
      Catalogue Number20-114
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPKA Inhibitor Cocktail
      References
      Product Information
      Presentation20mM MOPS, pH 7.2, 25mM β-glycerol phosphate, 5mM EGTA, 1mM sodium orthovanadate, 1mM dithiothreitol
      Quality LevelMQ100
      Applications
      Key Applications
      • Kinase Assay
      Application NotesFor use in kinase assays.
      Biological Information
      Entrez Gene Number
      Entrez Gene SummarycAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
      Gene Symbol
      • PRKACA
      • MGC102831
      • MGC48865
      • PKACA
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P17612 # Phosphorylates a large number of substrates in the cytoplasm and the nucleus.
      SIZE: 351 amino acids; 40590 Da
      SUBUNIT: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.
      SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm (By similarity).
      TISSUE SPECIFICITY: Isoform 2 is sperm specific.
      PTM: Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively (By similarity).
      SIMILARITY: SwissProt: P17612 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated as an inhibitor cocktail
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size1 mL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      20-114 04053252410444

      Documentation

      PKA Inhibitor Cocktail SDS

      Title

      Safety Data Sheet (SDS) 

      PKA Inhibitor Cocktail Certificates of Analysis

      TitleLot Number
      PKA Inhibitor Cocktail - 0702051768 0702051768
      PKA Inhibitor Cocktail - 30209 30209
      PKA Inhibitor Cocktail - 3256146 3256146
      PKA Inhibitor Cocktail - 3660786 3660786
      PKA Inhibitor Cocktail - 4105228 4105228
      PKA Inhibitor Cocktail - 4294873 4294873
      PKA Inhibitor Cocktail - Any-lot Any-lot
      PKA Inhibitor Cocktail - JBC1362505 JBC1362505
      PKA Inhibitor Cocktail -2472071 2472071
      PKA Inhibitor Cocktail -2830230 2830230