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539162 Proteasome Inhibitor II - Calbiochem

The Proteasome Inhibitor II controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Proteasome Inhibitor II - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (Benzyloxycarbonyl)-Leu-Leu-phenylalaninal, Z-LLF-CHO

Primary Target: MPC
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539162
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₉H₃₉N₃O₅
      Description
      OverviewA potent, cell-permeable, and reversible proteasome inhibitor. Inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (MPC; Ki = 460 nM). Does not inhibit the peptidyl-glutamyl peptide hydrolyzing activity of MPC even at concentrations of 200 µM. Also blocks the decay of IκB-α and IκB-β proteins in exponentially growing WEHI 231 cells.
      Catalogue Number539162
      Brand Family Calbiochem®
      Synonyms(Benzyloxycarbonyl)-Leu-Leu-phenylalaninal, Z-LLF-CHO
      References
      ReferencesSchauer, S.L., et al. 1998. J. Immunol. 160, 4398.
      Orlowski, M., et al. 1997. Biochemistry 36, 13946.
      Orlowski, M., et al. 1993. Biochemistry 32, 1563.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      Hill FormulaC₂₉H₃₉N₃O₅
      Chemical formulaC₂₉H₃₉N₃O₅
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMPC
      Primary Target K<sub>i</sub>460 nM against the pituitary multicatalytic proteinase complex (MPC)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Leu-Leu-Phe-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      539162 0

      Documentation

      Proteasome Inhibitor II - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Proteasome Inhibitor II - Calbiochem Certificates of Analysis

      TitleLot Number
      539162

      References

      Reference overview
      Schauer, S.L., et al. 1998. J. Immunol. 160, 4398.
      Orlowski, M., et al. 1997. Biochemistry 36, 13946.
      Orlowski, M., et al. 1993. Biochemistry 32, 1563.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Proteasomes Technical Bulletin
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-September-2008 RFH
      Synonyms(Benzyloxycarbonyl)-Leu-Leu-phenylalaninal, Z-LLF-CHO
      DescriptionA potent and cell-permeable proteasome inhibitor. Inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (MPC; Ki = 460 nM). Does not inhibit the peptidylglutamyl-peptide hydrolyzing (PGPH) activity of MPC even at concentrations of 200 µM. Also blocks the decay of IκB-α and IκB-β proteins in exponentially growing WEHI 231 cells.
      FormWhite lyophilized solid
      Chemical formulaC₂₉H₃₉N₃O₅
      Peptide SequenceZ-Leu-Leu-Phe-CHO
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from moisture
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.
      Toxicity Standard Handling
      ReferencesSchauer, S.L., et al. 1998. J. Immunol. 160, 4398.
      Orlowski, M., et al. 1997. Biochemistry 36, 13946.
      Orlowski, M., et al. 1993. Biochemistry 32, 1563.