Skip to Content
Merck

Key Documents

View All Documentation

8.14815

Sodium chlorite

(25% solution in water) for synthesis

Synonym(s):

Chlorous acid, sodium salt

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

NACRES:
NA.22
UNSPSC Code:
12352302
Grade:
synthesis grade
Form:
liquid
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

grade

synthesis grade

Quality Segment

200

vapor pressure

20 hPa ( 20 °C)

form

liquid

potency

1136 mg/kg LD50, oral (Rat)

reaction suitability

reagent type: oxidant

pH

12-13 (20 °C in H2O)

bp

≥100 °C/1013 hPa

mp

<-3 °C

density

1.20-1.25 g/cm3 at 20 °C

storage temp.

2-30°C

Application

Sodium chlorite (NaClO2) can be used as an oxidizing agent for the conversion of:
  • Aldehydes to corresponding carboxylic acids under mild reaction conditions in the presence of scavengers such as sulfamic acid or resorcinol.
  • Primary alcohols to carboxylic acids in the presence of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and NaOCl.
  • Aliphatic and aromatic thiols to the corresponding disulfides.
  • Aryl boronic acids to phenols via ipso-hydroxylation.
  • Cyclic benzylic ethers and N-protected cyclic benzylic amines to benzolactones and benzolactams.
  • Alkenes to epoxides using aldehydes as promoters.
  • Alkenes and cycloalkenes to 1, 2 diols via osmium-catalyzed Sharpless asymmetric dihydroxylation.

It can also be used in combination with Br2 to synthesize 2-carboxyazetidin-2-ones from furanylazetidinones.

Analysis Note

Assay (iodometric): 23.0 - 26.0 %
Density (d 20 °C/ 4 °C): 1.200 - 1.220

signalword

Danger

target_organs

spleen

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1 - STOT RE 2

supp_hazards

EUH032,EUH071

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Deleterious substance

pdsc

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library