324801
Epoxomicin
≥95% (HPLC), liquid, proteasome inhibitor, Calbiochem®
Synonyme(s) :
InSolution Epoxomicin, Synthetic, Proteasome Inhibitor XIV
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A propos de cet article
Formule empirique (notation de Hill) :
C28H50N4O7
Poids moléculaire :
554.72
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
liquid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Service technique
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Laissez-nous vous aiderNom du produit
Epoxomicin, InSolution, ≥95%
Quality Segment
assay
≥95% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
shipped in
wet ice
storage temp.
−20°C
General description
Cell permeable: No
Product does not compete with ATP.
Reversible: No
Epoxomicin is a highly effective and selective proteasome inhibitor thatexhibits significant anti-inflammatory properties in vivo. This potent antitumor agent specifically targets the proteasome. Epoxomicin exhibits a stronger inhibitory effect on chymotrypsin-like activity compared to lactacystin and the peptide vinyl sulfone (NLVS). This powerful natural producteffectively inhibits nuclear factor kappa B (NF-κB) activation in vitro and signific antly reduces inflammation in the murine ear edema assay. Epoxomicin prevents the degradation of IκB and inhibits the activation of NF-κBDNA-binding activity. It can stabilize p53 levels in cell culture. It is an irreversible inhibitor of chymotrypsin-like (CT-L), trypsin-like (T-L), and peptidylglutamyl peptide hydrolyzing (PGPH) activities of the proteasome. It modifies the proteasomal catalytic subunits LMP-7, MECL1, and Z[MJ2] .
Product does not compete with ATP.
Reversible: No
Epoxomicin is a highly effective and selective proteasome inhibitor thatexhibits significant anti-inflammatory properties in vivo. This potent antitumor agent specifically targets the proteasome. Epoxomicin exhibits a stronger inhibitory effect on chymotrypsin-like activity compared to lactacystin and the peptide vinyl sulfone (NLVS). This powerful natural producteffectively inhibits nuclear factor kappa B (NF-κB) activation in vitro and signific antly reduces inflammation in the murine ear edema assay. Epoxomicin prevents the degradation of IκB and inhibits the activation of NF-κBDNA-binding activity. It can stabilize p53 levels in cell culture. It is an irreversible inhibitor of chymotrypsin-like (CT-L), trypsin-like (T-L), and peptidylglutamyl peptide hydrolyzing (PGPH) activities of the proteasome. It modifies the proteasomal catalytic subunits LMP-7, MECL1, and Z[MJ2] .
Application
Epoxomicin has been used incell culture for proteasome inhibition experiments. It has also been used incell culture medium to treat MODE-K cells for stimulation to blockproteasome.
Packaging
Packaged under inert gas
Physical form
A 1 mM (50 µg/90 µl) solution of Epoxomicin, Synthetic (Cat. No. 324800) in DMSO.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
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Classe de stockage
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)
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