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5.05626

(S)-Sulpiride

Synonym(s):

(S)-Sulpiride, (S)-(-)-5-Aminosulfonyl-N-[(1-ethyl­-2-pyrrolidinyl)methyl]-2-methoxybenzamide, D2-like dopamine antagonist, (s)-Sulpiride, Sulpiride

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About This Item

Empirical Formula (Hill Notation):
C15H23N3O4S
CAS Number:
23672-07-3
Molecular Weight:
341.43
UNSPSC Code:
12352200
MDL number:
MFCD00055220
Assay:
≥99% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
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assay

≥99% (HPLC)

Quality Segment

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 100 mM

storage temp.

2-8°C

InChI

1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)

InChI key

BGRJTUBHPOOWDU-UHFFFAOYSA-N

General description

Dopamine D2 receptor antagonist with good aqueous solubility. S-sulpiride (200 nm) was used to confirm that dopamine currents were mediated through the D2 receptor in whole animal rat brain preps. IC50 of 0.01012 µM Antagonist activity at human dopamine D2 receptor expressed in CHOp cells assessed as inhibition of quinopirole-induced mitogenisis.

Biochem/physiol Actions

Primary Target
D2-like dopamine receptors

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Eagle, D. M. et al. 2011. J. Neurosci.31, 7349.
Banala, A. K. et al. 2011. J. Med. Chem.54, 3581.
Seeman, P. and Van Tol, H. H. 1994. Trends Pharmacol. Sci.15, 264.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Storage Class

11 - Combustible Solids

wgk

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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