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Merck

AB5905

Anti-Vesicular Glutamate Transporter 1 Antibody

CHEMICON®, guinea pig polyclonal

Synonym(s):

VGLUT1, BNPI

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
polyclonal
Species reactivity:
rat
Application:
immunohistochemistry
Technique(s):
immunohistochemistry: suitable
Citations:
617
Uniprot accession no.:
Q62634

Key Documents

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Product Name

Anti-Vesicular Glutamate Transporter 1 Antibody, serum, Chemicon®

biological source

guinea pig

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable

NCBI accession no.

NP_446311

UniProt accession no.

Q62634

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

rat ... Slc17A7(116638)

Application

  • Tested Applications

    Immunocytochemistry Analysis: A 1:250 dilution from a representative lot detected Vesicular Glutamate Transporter 1 in rat E18 cortical cells.
  • Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user

Biochem/physiol Actions

Recognizes Vesicular Glutamate Transporter 1 (VGLUT1, BNPI {Brain specific Na+ dependent inorganic phosphate cotransporter}). The antiserum has been tested on tissue sections from the rat central nervous system (CNS) using immunofluorescence histochemistry. The antiserum mainly labels nerve fibers and terminals. VGLUT1 is an excellent marker for glutamatergic nerve terminals. The staining pattern for the staining obtained with the VGLUT1 antiserum corresponds to the pattern described using other antisera to VGLUT1 (Bellocchio et al., 1998; Fremeau et al., 2001; Fujiyama et al., 2001; Sakata-Haga et al., 2001; Tong et al., 2001; Kaneko et al. 2002; Varoqui et al., 2002). Preabsorption of the VGLUT1 antiserum with immunogen peptide eliminates all immunostaining.

General description

62 kDa
Vesicular glutamate transporter 1 (VGLUT1) is encoded by the gene mapped to human chromosome 19q13. VGLUT1 is specifically expressed in neuronal cells in the brain. It is characterized with a conserved C-terminal dileucine-like motif and two polyproline domains distal to C- terminal end, including one that binds to endocytic BAR (Bin/Amphiphysin/Rvs) domain protein, endophilin.

Immunogen

Synthetic peptide from rat VGLUT1 protein with no overlap to VGLUT2. The immunogen is available as AG208.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Physical form

Guinea pig Serum in 0.1% Sodium Azide.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk

WGK 1

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

AB5905:

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Certificates of Analysis (COA)

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Assignment of SLC17A6 (alias DNPI), the gene encoding brain/pancreatic islet-type Na+-dependent inorganic phosphate cotransporter to human chromosome 11p14.3
Aihara Y, et al.
Cytogenetics and Cell Genetics (2001)
Depletion of spinal 5-HT accelerates mechanosensory recovery in the deafferented rat spinal cord
Cragg JJ, et al.
Experimental Neurology, 222(2), 277-284 (2010)
Xia Chen et al.
PloS one, 6(2), e17072-e17072 (2011-03-02)
The success of transplants of neural tissue into the adult dentate gyrus in generating mature neurons is highly variable. Here we address the roles of the origin of the tissue and its pre-implantation preparation, and show that both are critical.
The regulation of corticofugal fiber targeting by retinal inputs
Grant E, et al.
Cerebral Cortex, 26(3), 1336-1348 (2016)
Activation of NMDA Receptors in Lumbar Spinothalamic Cells is Required for Ejaculation.
Staudt MD, de Oliveira CV, Lehman MN, McKenna KE, Coolen LM.
Journal of Sexual Medicine null
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Global Trade Item Number

SKUGTIN
AB590504053252333897
AG20804053252282812

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