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Merck

T8656

Thiourea

ACS reagent grade, ≥99.0%

Synonym(s):

Sulfourea, Thiocarbamide

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About This Item

Linear Formula:
NH2CSNH2
CAS Number:
62-56-6
Molecular Weight:
76.12
NACRES:
NA.21
PubChem Substance ID:
24900549
UNSPSC Code:
12352100
EC Number:
200-543-5
MDL number:
MFCD00008067
Beilstein/REAXYS Number:
605327
Assay:
≥99.0%

Key Documents

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Product Name

Thiourea, ACS reagent, ≥99.0%

InChI

1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)

InChI key

UMGDCJDMYOKAJW-UHFFFAOYSA-N

SMILES string

NC(N)=S

grade

ACS reagent

assay

≥99.0%

ign. residue

≤0.1% (as SO4)

loss

≤0.5% loss on drying, 105°C, 2h

mp

170-176 °C (lit.), 174-177 °C

solubility

H2O: passes test

functional group

amine, thiourea

Quality Level

200

Gene Information

mouse ... Ephx2(13850)

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General description

Thiourea is an analogue of urea containing sulphur.

Application

Chaotropic agent; strong denaturant. Increases solubility and recovery of proteins
Thiourea has been used:
  • as a component of lysis buffer for liver tissue homogenization
  • in 2-D sample buffer for two-dimensional in-gel protein tyrosine phosphatases (PTP) assay
  • in rehydration buffer for protein extraction

Biochem/physiol Actions

Thiourea is a free radical scavenger of the peroxide radical. It was shown to inhibit lipid peroxidation and ultraviolet (UV)-induced crosslinking of collagen. Bud dormancy in plants can be inhibited by thiourea which is used as a growth stimulator. It is also known to be used in the treatment of hyperthyroidism.

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 2 - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Class I Designated Chemical Substances

prtr

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

T8656-50G:4548173951522 + T8656-BULK: + T8656-500G:4548173951515 + T8656-100G:4548173951508 + T8656-VAR: + T8656-5G:

jan

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Certificates of Analysis (COA)

Lot/Batch Number
0000506224
0000506226
0000506226
0000506224
0000480791

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Investigation of protein-tyrosine phosphatases by in-gel assays.
Markova B, et al.
Methods, 35(1), 22-27 (2005)
Effect of copper nanoparticles exposure in the physiology of the common carp (Cyprinus carpio): Biochemical, histological and proteomic approaches
Gupta YR, et al.
Aquaculture and Fisheries, 1(2), 15-23 (2016)
Mechanism of the reduction of methylene blue by thiourea in aqueous acidic medium
Osunlaja AA
International Journal of ChemTech Research, 4(2), 609-617 (2012)
Yoshiji Takemoto
Chemical & pharmaceutical bulletin, 58(5), 593-601 (2010-05-13)
We have developed several multifunctional thiourea catalysts bearing a tertiary amine or an 1,2-amino alcohol in expectation of their synchronous activation of a nucleophile and an electrophile through both acid-base and hydrogen-bonding interactions. From these studies, it was revealed that
Mireille Vonlanthen et al.
The Journal of organic chemistry, 78(8), 3980-3988 (2013-03-09)
Proof that sulfur is a viable reporting element for the development of fluorescent chemosensors for metal ions is presented. To date, the majority of metal-responsive fluorescent chemosensors have relied on metal-nitrogen coordination to provide a fluorescence response, most commonly by
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