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C2105

Z-Val-Ala-Asp fluoromethyl ketone

Name: Z-Val-Ala-Asp fluoromethyl ketone
Brand: SIGMA

≥90% (TLC), Caspase-1 inhibitor, powder

Synonym(s):

Z-VAD-FMK, Non-methylated

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₈FN₃O₇

CAS Number:

161401-82-7

Molecular Weight:

453.46

UNSPSC Code:

12352209

PubChem Substance ID:

329774926

NACRES:

NA.77

MDL number:

MFCD03452883

Assay:

≥90% (TLC)

Form:

powder

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Properties

Product Name

Z-Val-Ala-Asp fluoromethyl ketone, powder, ≥90% (TLC)

Quality Segment

200

assay

≥90% (TLC)

form

powder

shipped in

dry ice

storage temp.

−20°C

SMILES string

CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)CF

InChI

1S/C21H28FN3O7/c1-12(2)18(25-21(31)32-11-14-7-5-4-6-8-14)20(30)23-13(3)19(29)24-15(9-17(27)28)16(26)10-22/h4-8,12-13,15,18H,9-11H2,1-3H3,(H,23,30)(H,24,29)(H,25,31)(H,27,28)/t13-,15-,18-/m0/s1

InChI key

SUUHZYLYARUNIA-YEWWUXTCSA-N

Description

Biochem/physiol Actions

Non-methylated competitive and irreversible inhibitor of caspase-1, as well as other caspases, which can be used directly with purified enzymes. It does not require esterase to hydrolyze the O-methyl ester like the cell-permeable form, Z-Val-Ala-Asp(OMe) fluoromethyl ketone (Product Code V-116).

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

C2105-3MG-PW: + C2105-3MG: + C2105-VAR: + C2105-BULK:

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