116850 Adenylyl Cyclase Type V Inhibitor, NKY80 - CAS 299442-43-6 - Calbiochem

116850
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概要

Replacement Information

主要スペック表

Empirical FormulaCAS #
C₁₂H₁₁N₃O₂ 299442-43-6

価格&在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
116850-25MGCN
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      樹脂アンプル 25 mg
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      116850-5MGCN
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          樹脂アンプル 5 mg
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          Description
          OverviewA cell-permeable quinazolinone containing a non-nucleoside compound that acts as a potent, selective inhibitor of adenylyl cyclase (AC) type V isoform (IC50 = 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively) in the presence of Gsα GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Regulates the AC catalytic activity in heart and lung tissues.
          Catalogue Number116850
          Brand Family Calbiochem®
          Synonyms2-Amino-7-(furanyl)-7,8-dihydro-5(6H)-quinazolinone
          References
          ReferencesOnda, T., et al. 2001. J. Biol. Chem. 276, 47785.
          Product Information
          CAS number299442-43-6
          ATP CompetitiveN
          FormPale orange solid
          Hill FormulaC₁₂H₁₁N₃O₂
          Chemical formulaC₁₂H₁₁N₃O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetAdenylate cyclase (AC) type V isoform
          Primary Target IC<sub>50</sub>8.3 µM, 132 µM and 1.7 mM for type V, III and II, of adenylyl cyclase (AC), respectively, in the presence of Gsα GTPγS-Forskolin
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Adenylyl Cyclase Type V Inhibitor, NKY80 - CAS 299442-43-6 - Calbiochem (M)SDS

          タイトル

          英語版製品安全データシート((M)SDS) 

          Adenylyl Cyclase Type V Inhibitor, NKY80 - CAS 299442-43-6 - Calbiochem 試験成績書(CoA)

          タイトルロット番号
          116850

          参考資料

          参考資料の概要
          Onda, T., et al. 2001. J. Biol. Chem. 276, 47785.
          データシート

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-April-2011 RFH
          Synonyms2-Amino-7-(furanyl)-7,8-dihydro-5(6H)-quinazolinone
          DescriptionA cell-permeable, non-nucleoside compound that acts as a potent, and selective inhibitor of adenylyl cyclase (AC) type V (IC50 = 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively) in the presence of G5α GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Reported to regulate AC catalytic activity in heart and lung tissues.
          FormPale orange solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number299442-43-6
          Chemical formulaC₁₂H₁₁N₃O₂
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (200 mg/ml) or Methanol (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesOnda, T., et al. 2001. J. Biol. Chem. 276, 47785.