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MABE611 Anti-BANF1, clone EPR7668, Rabbit Monoclonal Antibody

MABE611
100 µL  
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      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IHC Rb Unpurified Monoclonal Antibody
      Description
      Catalogue NumberMABE611
      DescriptionAnti-BANF1, clone EPR7668, Rabbit Monoclonal Antibody
      Alternate Names
      • Barrier-to-autointegration factor
      • Breakpoint cluster region protein 1
      • BANF1
      • BAF
      • BCRG1
      Background InformationBarrier-to-autointegration factor (BANF1, BAF), also known as Breakpoint cluster region protein 1 (BCRG1), plays a critical role chromatin organization as well as subsequent gene expression particularly in embryonic stem cells (ESCs) development where it is required to maintain self-renewal potential. BANF1 initial naming comes from its interaction with viral proteins during infection. Various retroviruses, including HIV-1, make use of BANF1 protein to protect their DNA from normal autointegration destruction functions, and thus allowing viral integration in the host DNA chromosome. BANF1 is localized primarily in the nucleus but can be found in the cytoplasm as well, but during mitosis it is specifically localized to the chromosomes. The protein can bind dsDNA and nuclear membrane proteins and is thought to also play a role in chromatin positioning with respect to the nuclear periphery. There appear to be multiple isoforms as well. EMD-Millipore’s Anti-BANF1 rabbit monoclonal antibody has been tested in western blot on HeLa, HepG2 and 293T human cell lysates and in immunohistochemistry on paraffin embedded thyroid gland carcinoma tissue.
      References
      Product Information
      FormatUnpurified
      PresentationRabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-BANF1 antibody is validated for use in WB, IH for the detection of BANF1.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:100-250 dilution from a representative lot detected BANF1 in human colonic carcinoma tissue.

      Produced in collaboration with Epitomics™
      Biological Information
      ImmunogenSynthetic peptide corresponding to human BANF1.
      CloneEPR7668
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityEquilibrium disassociation constant (KD) is 2.18 x 10 -10 M
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • BANF1
      • BAF
      • BCRG1
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~10 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa, HepG2, and HEK293 cell lysates.

      Western Blotting Analysis: A 1:1,000-10,000 dilution of this antibody detected BANF1 in HeLa, HepG2, and HEK293 cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

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      カテゴリー

      Life Science Research > Antibodies and Assays > Primary Antibodies