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AB10526 Anti-COX4 Antibody

AB10526
100 µg  
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      概要

      Replacement Information

      Special Offers[海外情報]

      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB10526
      DescriptionAnti-COX4 Antibody
      Alternate Names
      • cytochrome c oxidase subunit IV isoform 1
      • cytochrome c oxidase subunit IV1
      • Cytochrome c oxidase polypeptide IV
      • cytochrome c oxidase subunit 4 isoform 1, mitochondrial
      Background InformationCytochrome C oxidase subunit 4 (COX4), is one of 13 subunits of cytochrome c oxidase. Cytochrome c oxidase is responsible for catalyzing the last step of electron transfer through the respiratory chain on the mitochondrial inner membrane. COX4 assembles into sub-complexes with other subunits of cytochrome c oxidase and may represent a rate-limiting intermediate.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Human fetal skeletal muscle tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-COX4 Antibody detects level of COX4 & has been published & validated for use in WB, IH(P).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:500 dilution from a previous lot detected COX4 in normal human cardiac muscle tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human COX4.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Species Reactivity NoteDemonstrated to react with human.
      Other homologies: Rat and mouse (59% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryCytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. [provided by RefSeq].
      Gene Symbol
      • COX4
      • COXIV
      • COX4-1
      • COX IV-1
      • COX4I1
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

      SUBCELLULAR LOCATION: Mitochondrion inner membrane.

      TISSUE SPECIFICTY: Ubiquitous.

      SEQUENCE SIMILARITIES: Belongs to the cytochrome c oxidase IV family.
      Molecular Weight ~17 kDa observed.
      A non-specific band may be observed at ~58 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human fetal skeletal muscle tissue lysate.

      Western Blot Analysis: 0.1 µg/mL of this antibody detected COX4 in 10 µg of human fetal skeletal muscle tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-COX4 Antibody (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      Anti-COX4 Antibody 試験成績書(CoA)

      タイトルロット番号
      Anti-COX4 (rabbit polyclonal) Polyclonal Antibody Q2922240
      Anti-COX4 - 2356329 2356329
      Anti-COX4 - 2388992 2388992
      Anti-COX4 - 2197239 2197239
      Anti-COX4 - 2283892 2283892
      Anti-COX4 - 3321839 3321839
      Anti-COX4 - 3462108 3462108
      Anti-COX4 - 3517542 3517542
      Anti-COX4 - NG1944101 NG1944101
      Anti-COX4 - NRG1831976 NRG1831976

      参考資料

      参考資料の概要アプリケーションPub Med ID
      Jumonji domain containing protein 6 (Jmjd6) modulates splicing and specifically interacts with arginine-serine-rich (RS) domains of SR- and SR-like proteins.
      Heim, A; Grimm, C; Müller, U; Häußler, S; Mackeen, MM; Merl, J; Hauck, SM; Kessler, BM; Schofield, CJ; Wolf, A; Böttger, A
      Nucleic Acids Res  42  7833-50  2014

      概要を表示する
      Immunoprecipitation24914048 24914048
      Cytosolic malate dehydrogenase regulates senescence in human fibroblasts.
      Seung-Min Lee,So Hee Dho,Sung-Kyu Ju,Jin-Soo Maeng,Jeong-Yoon Kim,Ki-Sun Kwon
      Biogerontology  13  2012

      概要を表示する
      22971926 22971926