MABC187 Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132S Antibody, clone SMab-1

MABC187
100 µL  
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      概要

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      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, ICC, IHC M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABC187
      DescriptionAnti-Isocitrate Dehydrogenase 1 (IDH1)-R132S Antibody, clone SMab-1
      Alternate Names
      • Isocitrate dehydrogenase [NADP] cytoplasmic
      • IDH
      • Cytosolic NADP-isocitrate dehydrogenase
      • IDP
      • NADP(+)-specific ICDH
      • Oxalosuccinate decarboxylase
      Background InformationIsocitrate dehydrogenase 1 (IDH1) is a 46 kDa NADP-dependent enzyme, which catalyzes the decarboxylation of isocitrate into α-ketoglutarate. IDH1 may also play a role in the prevention of oxidative damage, and the shuttling of proteins to peroxisomes. It is widely reported that mutations in IDH1 result in multiple forms of gliomas. The Arginine to Serine substitution at amino acid 132 is seen in gliomas, abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate.
      References
      Product Information
      FormatPurified
      Control
      • S8 overexpressing CHO cell lysate
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-Isocitrate Dehydrogenase 1 (IDH1)-R132S Antibody, clone SMab-1 is an antibody against Isocitrate Dehydrogenase 1 (IDH1)-R132S for use in Western Blotting, ICC & IHC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Immunohistochemistry
      Application NotesWestern Blot Analysis: A 1:250 dilution from a representative lot detected Isocitrate Dehydrogenase 1 (IDH1)-R132S in a panel of CHO cell lysates expressing wild-type and mutated IDH1.

      Immunocytochemistry Analysis: A representative lot from an independent laboratory detected Isocitrate Dehydrogenase 1 (IDH1)-R123S in gliblastoma tissues that express the IDH1-R132S mutation.

      Immunohistochemistry Analysis: A representative lot from an independent laboratory detected Isocitrate Dehydrogenase 1 (IDH1)-R123S in IDH1-R132S-transfected LN229 cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Isocitrate Dehydrogenase 1 (IDH1)-R132S.
      CloneSmab-1
      HostMouse
      SpecificityThis antibody only detects the R132S mutation of Isocitrate Dehydrogenase (IDH1).
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • IDH1
      • PICD
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~50 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in S8 overexpressing CHO cell lysate.

      Western Blot Analysis: A 1:2,000 dilution from a representative lot detected Isocitrate Dehydrogenase 1 (IDH1)-R132S in S8 overexpressing CHO cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      試験成績書(CoA)

      タイトルロット番号
      Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132S2478931
      Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132S, clone SMab-1 - Q2054375Q2054375
      Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132S, clone SMab-1 -25948702594870
      Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132S, clone SMab-1 Monoclonal Antibody3090070
      Anti-Isocitrate Dehydrogenase 1 -27102092710209
      Anti-Isocitrate Dehydrogenase 1 -27912042791204

      参考資料

      参考資料の概要Pub Med ID
      Establishment of a novel monoclonal antibody SMab-1 specific for IDH1-R132S mutation.
      Kaneko, Mika Kato, et al.
      Biochem. Biophys. Res. Commun., 406: 608-13 (2011)  2011

      概要を表示する
      21352804 21352804

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      カテゴリー

      Life Science Research > Antibodies and Assays > Primary Antibodies