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MABF220 Anti-mA20 Antibody/TNFAIP3, clone 37

MABF220
100 µg  
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      概要

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      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M FC R Purified Monoclonal Antibody
      Description
      Catalogue NumberMABF220
      DescriptionAnti-mA20 Antibody/TNFAIP3, clone 37
      Alternate Names
      • Tumor necrosis factor alpha-induced protein 3
      • TNF alpha-induced protein 3
      • Putative DNA-binding protein A20
      • Zinc finger protein A20
      Background InformationTNFAIP3/mA20, also known as Tumor necrosis factor alpha-induced protein 3, OTU domain-containing protein 7C, Putative DNA-binding protein A20, or Zinc finger protein A20, and encoded by the gene TNFAIP3/OTUD7C, is an ubiquitin editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. TNFAIP3/mA20 is involved in immune and inflammatory responses signaled by cytokines or pathogens through the Toll-like receptors and ultimately regulating NF-kappa-B activity. TNFAIP3/mA20 is an essential component of the ubiquitin editing protein complex consisting of RNF11, ICTH, and TAX1BP1 and ensures the transient nature of inflammatory signaling. TNFAIP3/mA20 is also a key player in switching of Lys-63 polyubiquitinated chains to Lys-48 polyubiquitinated chains for the subsequent degradation of specific targets as well. TNFAIP3/mA20 is located in the cytoplasm but can be found in the nucleus and lysosome depending upon the microenvironment and stimulus.
      References
      Product Information
      FormatPurified
      PresentationPurified rat monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect mA20/TNFAIP3 using this Anti-mA20 Antibody/TNFAIP3, clone 37 validated for use in flow cytometry.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenRecombinant protein corresponding to Mouse mA20/TNFAIP3.
      Clone37
      Concentration0.5 mg/mL
      HostRat
      IsotypeIgMκ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Tnfaip3
      • Tnfip3
      Purification MethodPurified by Ion-Exchange Chromatography
      UniProt Number
      Molecular Weight90 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in mouse splenocytes.

      Flow Cytometry Analysis: 2 µg of this antibody detected mA20/TNFAIP3 in 1X10E6 mouse splenocytes.

      This antibody was produced in collaboration with the Scripps Research Institute.For Scripps Research Institute Validation (Click Here)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications