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533796 Asparagine Endopeptidase Inhibitor, AENK

533796
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概要

Replacement Information

主要スペック表

Empirical Formula
C₃₃H₄₃N₇O₉

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      ガラスビン 10 mg
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      Description
      OverviewAn amino and carboxy-terminal blocked tetra peptide that acts as a specific, competitive inhibitor of the protease activity of asparagine endopeptidase (AEP), an enzyme that cleaves substrates on the C-terminal side of asparagine. Believed to act as a competitive substrate that itself is hydrolyzed by AEP. Shown to block processing of tetanus toxin antigen (TTCF) in vitro (~1 mg/ml) and retard TTCF presentation to T cells in vivo. Does not affect the cleavage of cathepsin B/L and cathepsin S substrates. Shown to selectively and completely suppress tau cleavage by AEP (~ 1 mg/ml).

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number533796
      Brand Family Calbiochem®
      SynonymsFmoc-Ala-Glu-Asn-Lys-NH2, Asparagine Endopeptidase Inhibitor, AENK, AEP Inhibitor, AENK
      References
      ReferencesZhang, Z., et al. 1999. Nat. Med. 20, 1254.
      Monoury, B., et al. 1998. Nat. 396, 695.
      Product Information
      FormWhite solid
      FormulationSupplied as a TFA salt.
      Hill FormulaC₃₃H₄₃N₇O₉
      Chemical formulaC₃₃H₄₃N₇O₉
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAEP
      Purity≥98% by HPLC
      Physicochemical Information
      Peptide SequenceFmoc-Ala-Glu-Asn-Lys-NH2
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Asparagine Endopeptidase Inhibitor, AENK (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      参考資料

      参考資料の概要
      Zhang, Z., et al. 1999. Nat. Med. 20, 1254.
      Monoury, B., et al. 1998. Nat. 396, 695.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-July-2016 JSW
      SynonymsFmoc-Ala-Glu-Asn-Lys-NH2, Asparagine Endopeptidase Inhibitor, AENK, AEP Inhibitor, AENK
      DescriptionAn amino and carboxy-terminal blocked tetra peptide that acts as a specific, competitive inhibitor of the protease activity of asparagine endopeptidase (AEP), an enzyme that cleaves substrates on the C-terminal side of asparagine. Believed to act as a competitive substrate that itself is hydrolyzed by AEP. Shown to block processing of tetanus toxin antigen (TTCF) in vitro (~1 mg/ml) and retard TTCF presentation to T cells in vivo. Does not affect the cleavage of cathepsin B/L and cathepsin S substrates. Shown to selectively and completely suppress tau cleavage by AEP (~ 1 mg/ml).
      FormWhite solid
      FormulationSupplied as a TFA salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₃H₄₃N₇O₉
      Peptide SequenceFmoc-Ala-Glu-Asn-Lys-NH2
      Purity≥98% by HPLC
      SolubilityH₂O (25 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesZhang, Z., et al. 1999. Nat. Med. 20, 1254.
      Monoury, B., et al. 1998. Nat. 396, 695.