138000 D-Amino Acid Oxidase Inhibitor - CAS 39793-31-2 - Calbiochem

138000
価格&在庫状況を照会

概要

Replacement Information

主要スペック表

Empirical FormulaCAS #
C₇H₅NO₂S 39793-31-2

価格&在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
138000-50MGCN
在庫状況検索中…
現在国内在庫なし現在国内在庫なし
現在国内在庫有り 
販売中止
在庫僅少
現在国内在庫あり
    Remaining : Will advise
      Remaining : Will advise
      注文対象外
      お問合せください
      Contact Customer Service

      樹脂アンプル 50 mg
      価格を検索中…
      価格が見つかりません
      Minimum Quantity needs to be mulitiple of
      弊社照会 詳細を表示 
      値引
      ()
       
      弊社照会
      Description
      OverviewA cell-permeable thienopyrrole compound that potently inhibits the cellular activity of transfected D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) in CHO cells (IC50 against human and rat DAO = 145 and 114 nM, respectively), while exhibiting no activity towards D-aspartate oxidase (DDO; IC50 >5 µM), P450 enzymes CYP3A4/2D6/3C9 (IC50 >10 µM), and a panel of over 150 other enzymes, receptors, and ion channels. Although in vivo treatment of Compound 8 (200 mg/kg, i.p.) is shown to effectively inhibit DAO activity in rat brain and kidney (by 96% and 80%, respectively), the resulting D-serine concentration increase in the periphery and central nervous system appears to be far from sufficient to produce adequate antipsychotic and cognitive enhancing effects.
      Catalogue Number138000
      Brand Family Calbiochem®
      Synonyms4H-Thieno[3,2-b]pyrrole-5-carboxylic acid, D-AAO Inhibitor, Compound 8
      References
      ReferencesSmith, S.M., et al. 2009. J. Pharmacol. Exp. Ther. 328, 921.
      Sparey, T., et al. 2008. Bioorg. Med. Chem. Lett. 18, 3386.
      Product Information
      CAS number39793-31-2
      FormBeige solid
      Hill FormulaC₇H₅NO₂S
      Chemical formulaC₇H₅NO₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22-36/37/38

      Harmful if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36/37/39

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      D-Amino Acid Oxidase Inhibitor - CAS 39793-31-2 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      D-Amino Acid Oxidase Inhibitor - CAS 39793-31-2 - Calbiochem 試験成績書(CoA)

      タイトルロット番号
      138000

      参考資料

      参考資料の概要
      Smith, S.M., et al. 2009. J. Pharmacol. Exp. Ther. 328, 921.
      Sparey, T., et al. 2008. Bioorg. Med. Chem. Lett. 18, 3386.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-August-2009 RFH
      Synonyms4H-Thieno[3,2-b]pyrrole-5-carboxylic acid, D-AAO Inhibitor, Compound 8
      DescriptionA cell-permeable thienopyrrole compound that potently inhibits the cellular activity of transfected D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) in CHO cells (IC50 against human and rat DAO = 145 and 114 nM, respectively), while exhibiting no activity towards D-aspartate oxidase (DDO; IC50 >5 µM), P450 enzymes CYP3A4/2D6/3C9 (IC50 >10 µM), and a panel of over 150 other enzymes, receptors, and ion channels. Although in vivo treatment of Compound 8 (200 mg/kg, i.p.) is shown to effectively inhibit DAO activity in rat brain and kidney (by 96% and 80%, respectively), the resulting D-serine concentration increase in the periphery and central nervous system appears to be far from sufficient to produce adequate antipsychotic and cognitive enhancing effects.
      FormBeige solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number39793-31-2
      Chemical formulaC₇H₅NO₂S
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (80 mg/ml) or 5% NaOH (25 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Toxicity Harmful
      ReferencesSmith, S.M., et al. 2009. J. Pharmacol. Exp. Ther. 328, 921.
      Sparey, T., et al. 2008. Bioorg. Med. Chem. Lett. 18, 3386.