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171264 InSolution™ AMPK Inhibitor, Compound C•2HCl - CAS 866405-64-3 - Calbiochem

171264
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
866405-64-3C₂₄H₂₅N₅O

価格&在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
171264-2MGCN
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      ガラスビン 2 mg
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      Description
      OverviewA cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM in the presence of 5 µM ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCθ, PKA, or JAK3. Blocks celluar activities induced by AICAr (Cat. No. 123040) or Metformin (Cat. No. 317240). Induces weight loss by attenuating AMPK-mediated food intake in mice. The solid form of this compound (Cat. No. 171260) is also available.
      Catalogue Number171264
      Brand Family Calbiochem®
      Synonyms6-(4-(2-Piperidin-1-yl-ethoxy)-phenyl)-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, 2HCl, H₂O, Compound C, 2HCl, H₂O, AMPK Inhibitor I
      References
      ReferencesYu, P.B., et al. 2008. Nat. Chem. Biol 4, 33.
      Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
      Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
      Inoki, K., et al. 2003. Cell 115, 577.
      Fryer, L.G., 2002. FEBS Lett. 531, 189.
      Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
      Product Information
      CAS number866405-64-3
      FormLiquid
      FormulationA 10 mM (2 mg/408 µl) solution of AMPK Inhibitor, Compound C, 2HCl, (Cat. No. 171260) in H₂O.
      Hill FormulaC₂₄H₂₅N₅O
      Chemical formulaC₂₄H₂₅N₅O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing intial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ AMPK Inhibitor, Compound C•2HCl - CAS 866405-64-3 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      InSolution™ AMPK Inhibitor, Compound C•2HCl - CAS 866405-64-3 - Calbiochem 試験成績書(CoA)

      タイトルロット番号
      171264

      参考資料

      参考資料の概要
      Yu, P.B., et al. 2008. Nat. Chem. Biol 4, 33.
      Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
      Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
      Inoki, K., et al. 2003. Cell 115, 577.
      Fryer, L.G., 2002. FEBS Lett. 531, 189.
      Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.

      カタログ

      タイトル
      New Products: Volume 3, 2012
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-April-2012 JSW
      Synonyms6-(4-(2-Piperidin-1-yl-ethoxy)-phenyl)-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, 2HCl, H₂O, Compound C, 2HCl, H₂O, AMPK Inhibitor I
      DescriptionA cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM in the presence of 5 µM ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCθ, PKA, or JAK3. Blocks celluar activities induced by AICAr (Cat. No. 123040) or Metformin (Cat. No. 317240). Induces weight loss by attenuating AMPK-mediated food intake in mice.
      FormLiquid
      FormulationA 10 mM (2 mg/408 µl) solution of AMPK Inhibitor, Compound C, 2HCl, (Cat. No. 171260) in H₂O.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number866405-64-3
      Chemical formulaC₂₄H₂₅N₅O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing intial thaw, aliquot and freeze (-20°C).
      ReferencesYu, P.B., et al. 2008. Nat. Chem. Biol 4, 33.
      Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
      Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
      Inoki, K., et al. 2003. Cell 115, 577.
      Fryer, L.G., 2002. FEBS Lett. 531, 189.
      Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.