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880124X

Avanti

DSPE-PEG(2000) Folate

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-2000] (ammonium salt):methanol (9:1)

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About This Item

CAS Number:
1236288-25-7
MDL number:
MFCD28143627
NACRES:
NA.25
UNSPSC Code:
12352211
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Product Name

DSPE-PEG(2000) Folate, Avanti Research™ - A Croda Brand

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (880124X-10mg), pkg of 1 × 1 mL (880124X-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

concentration

1 mg/mL (880124X-1mg), 10 mg/mL (880124X-10mg)

shipped in

dry ice

storage temp.

−20°C

General description

DSPE-PEG(2000) Folate, also known as 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-2000], is a functionalized PEG lipid. This lipid is added into liposomes as a targeting ligand for folate receptors, which acts as cellular surface markers for numerous solid tumors and myeloid leukemias. Folate targeted drug delivery is used an effective therapy for the treatment and imaging of various cancers and inflammatory diseases. Folate conjugates with low molecular weight and high binding affinity for folate receptors (FR) on cell surface deliver a variety of molecular complexes such as protein toxins, immune stimulants, chemotherapeutic agents, liposomes, nanoparticles, and imaging agents to pathologic cells without affecting normal tissues.

Application

DSPE-PEG(2000) Folate(1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-2000]) may be used in preparation of folate-conjugated liposomes and folate-modified microvesicles (MVs).

Packaging

5 mL Clear Glass Sealed Ampule (880124X-10mg)
5 mL Clear Glass Sealed Ampule (880124X-1mg)

Preparation Note

Soluble in ethanol, DMSO, and Chloroform:Methanol:Ammonia (80:20:2) at 5mg/mL

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

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Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 2 - STOT SE 3

target_organs

Eyes,Central nervous system, Liver,Kidney, Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

80.6 °F

flash_point_c

27 °C

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

67-56-1 + 67-66-3

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