420122
JAK3 Inhibitor V
The JAK3 Inhibitor V, also referenced under CAS 932258, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
JAK3 Inhibitor V, (2-Naphthylvinyl Ketone), ZM 449829
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About This Item
Empirical Formula (Hill Notation):
C13H10O
CAS Number:
Molecular Weight:
182.22
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
waxy solid
Storage condition:
OK to freeze, desiccated, protect from light
Quality Segment
assay
≥98% (HPLC)
form
waxy solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated, protect from light
color
white
solubility
DMSO: 10 mg/mL, ethanol: 10 mg/mL
shipped in
wet ice
storage temp.
−20°C
InChI
1S/C13H10O/c1-2-13(14)12-8-7-10-5-3-4-6-11(10)9-12/h2-9H,1H2
InChI key
FOTCGZPFSUWZBN-UHFFFAOYSA-N
General description
A breakdown product of JAK3 Inhibitor IV (Cat. No. 420121) with similar inhibitory potency (pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1). Also inhibits STAT-5 phosphorylation and T-cell proliferation.
A breakdown product of JAK3 Inhibitor-IV (Cat. No. 420121) with similar inhibitory potency (pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1). Also inhibits STAT-5 phosphorylation and T-cell proliferation.
Biochem/physiol Actions
Cell permeable: no
Product does not compete with ATP.
Reversible: no
pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in DMSO; reconstitute just prior to use.
Other Notes
Brown, G.R., et al. 2000. Bioorg. Med. Chem. Lett.10, 575.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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