5.04479
JNJ 16259685 - CAS 409345-29-5 - Calbiochem
Synonym(s):
JNJ 16259685 - CAS 409345-29-5 - Calbiochem, (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone
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About This Item
Empirical Formula (Hill Notation):
C20H23NO3
CAS Number:
Molecular Weight:
325.40
UNSPSC Code:
12352200
assay
≥98% (TLC)
Quality Segment
form
solid
potency
0.55 nM IC50, 0.34 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white to off-white
solubility
DMSO: 25 mM
storage temp.
2-8°C
General description
An extremely potent, non-competitive antagonist for mGlu receptor subtype 1 (Ki = 0.34 nM; IC50 = 0.55 nM). 400-fold more selective for mGlu1 than for mGlu5 and no interaction with mGlu2, mGlu3, mGlu4, mGlu6, AMPA or NMDA receptors (IC50 >10 µM). Centrally active following systemic administration. Widely used for studying substance abuse, learning and memory, and neural plasticity.
Biochem/physiol Actions
Primary Target
mGlu₁
mGlu₁
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Lavreysen, H., et al. 2004. Neuropharmacology.47, 961.
Steckler, T., et al. 2005. Psychopharmacology.179, 198.
Steckler, T., et al. 2005. Behav. Brain. Res.164, 52.
Mabire, D., et al. 2005. J. Med. Chem.48, 2134.
Fukunaga, I., et al. 2007. Br. J. Pharmacol.151, 870.
Knopfel, T., et al. 2007. Br. J. Pharmacol.151, 723.
Achat-Mendes, C., et al. 2012. J. Pharmacol. Exp. Ther.343, 214.
Steckler, T., et al. 2005. Psychopharmacology.179, 198.
Steckler, T., et al. 2005. Behav. Brain. Res.164, 52.
Mabire, D., et al. 2005. J. Med. Chem.48, 2134.
Fukunaga, I., et al. 2007. Br. J. Pharmacol.151, 870.
Knopfel, T., et al. 2007. Br. J. Pharmacol.151, 723.
Achat-Mendes, C., et al. 2012. J. Pharmacol. Exp. Ther.343, 214.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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