5.04906
Cuspin-1
Synonym(s):
Cuspin-1, (5-Bromo-3-pyridinyl)(4-methylphenyl)methanone, Survival Motor Neuron protein Upregulator, Cuspin-1
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C13H10BrNO
CAS Number:
Molecular Weight:
276.13
UNSPSC Code:
12352200
Assay:
≥94% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light
assay
≥94% (HPLC)
Quality Segment
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
brown
solubility
DMSO: 10 mg/mL
storage temp.
2-8°C
General description
A cell-permeable pyridinylphenyl-methanone compound that is reported to effectively upregulate SMN (survival of motor neuron) protein level in 3 out of 4 SMA (spinal muscular atrophy) patient-derived fibroblast lines (by 71% to 93% increase in 48 h; 5 µg/mL), but not HT1080, 293T, A549, two human ESC-MN lines, MEF, mESC-MN, rat PC12, or rat ST14A cells. Shown to preferentially stimulate cellular Erk (Thr202/Tyr204) over Akt (Ser473) phosphorylation in SMA fibroblast line 9677 in a time-dependent manner (tmax = 24 h; 10 µg/mL), indicative of Ras-Raf-MEK signaling pathway activation.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Ras
Ras
Reversible: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Letso, R.R., et al. 2013. ACS Chem. Biol.8, 914.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Still not finding the right product?
Explore all of our products under Cuspin-1
Storage Class
11 - Combustible Solids
wgk
WGK 3
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.