グリシン

Name: グリシン
Brand: SIAL

meets analytical specification of Ph. Eur., BP, USP, 99-101% (based on anhydrous substance)

別名:

アミノエタン酸, アミノ酢酸, グリココール

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この商品について

化学式:

NH₂CH₂COOH

CAS番号:

56-40-6

分子量:

75.07

NACRES:

NA.21

PubChem Substance ID:

57647473

eCl@ss:

32160406

UNSPSC Code:

12352209

EC Number:

200-272-2

MDL number:

MFCD00008131

Beilstein/REAXYS Number:

635782

主要文書

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InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

SMILES string

NCC(O)=O

assay

99-101% (based on anhydrous substance)

form

crystalline powder

quality

meets analytical specification of Ph. Eur., BP, USP

technique(s)

IR spectroscopy: suitable

impurities

hydrolyzable substances, complies, organic volatile impurities, complies (GC), residual solvents, complies, ≤0.001% heavy metals (as Pb), ≤1.0% ninhydrin-positive substances

ign. residue

≤0.1% (as SO₄)

loss

≤0.2% loss on drying, 105 °C, 2 h

color

white

pH

5.9-6.4 (20 °C, 5%)

pKa (25 °C)

(1) 2.35, (2) 9.60, 2.35

mp

240 °C (dec.) (lit.)

solubility

H₂O: soluble 25 gm in 100 ml at 25 degrees c, H₂O: soluble 39.1 gm in 100 ml at 50 degrees c, alcohol: soluble 0.06 gm in 100 gm (Absolute), pyridine: soluble 164 parts, alcohol: very slightly soluble, diethyl ether: very slightly soluble

anion traces

chloride (Cl^-): ≤50 mg/kg, sulfate (SO₄^2-): ≤50 mg/kg

suitability

complies for appearance of solution, complies for reaction against H₂SO₄, in accordance for identity (IR)

Quality Level

200

Gene Information

rat ... Grin2a(24409)

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Application

Glycine was used for preparing platelets from whole-blood samples and study the stimulation of cytokine expression in leukocytes. It was used for biochemical and tolerance tests.

Biochem/physiol Actions

脊髄における抑制性神経伝達物質であり、NMDAレセプターのアロステリック調節因子です。

Glycine has a pivotal role in lowering the plasma lipid levels in diabetic and obese patients by activating the CNS. During brain hypoxia glycine can stabilize the energetics disturbances in brain mitochondria. It also increases the in vitro development of porcine blastocysts when used along with glucose.

保管分類

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

15527-6X500G-R: + 15527-6X2.5KG-R: + 15527-2.5KG-R: + 15527-BULK-R: + 15527-6X1KG-R: + 15527-1KG-R: + 15527-500G-R: + 15527-25KG-R: + 15527-50KG-R: + 15527-VAR-R:

jan

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Mechanism underlying the protective effect of glycine in energetic disturbances in brain tissues under hypoxic conditions.

A A Selin et al.

Bulletin of experimental biology and medicine, 153(1), 44-47 (2012-07-19)

Glycine stabilizes energetics of brain mitochondria under conditions of brain hypoxia in vivo modeled by ligation of the common carotid artery in rats. Hypoxia reduced respiratory control in brain cortex mitochondria from 7.7 ± 0.5 to 4.5 ± 0.3. Preliminary

Characterization of "Campylobacter pyloridis" by culture, enzymatic profile, and protein content.

F Megraud et al.

Journal of clinical microbiology, 22(6), 1007-1010 (1985-12-01)

"Campylobacter pyloridis" has been recently described as a gastritis-associated bacterium. We studied 20 strains. The bacteria had most of the characteristics of Campylobacter spp. strains. They were hippurate negative and tolerant to triphenyl tetrazolium chloride (at 0.4 and 1 mg/ml).

Glucose and glycine synergistically enhance the in vitro development of porcine blastocysts in a chemically defined medium.

Tomomi Mito et al.

Reproduction, fertility, and development, 24(3), 443-450 (2012-03-10)

In the present study, the effects of glucose and/or glycine on the in vitro development of Day 5 (Day 0=IVF) porcine blastocysts were determined. The addition of 2.5-10 mM glucose to the chemically defined culture medium porcine zygote medium (PZM)-5

Glycine normalizes hepatic triglyceride-rich VLDL secretion by triggering the CNS in high-fat fed rats.

Jessica T Y Yue et al.

Circulation research, 110(10), 1345-1354 (2012-04-05)

Dysregulation of hepatic triglyceride (TG)-rich very low-density lipoproteins (VLDL-TG) in obesity and type 2 diabetes contributes to the dyslipidemia that leads to cardiovascular morbidity. The central nervous system (CNS), particularly the hypothalamus, regulates hepatic lipid metabolism. Although the underlying neurocircuitry

Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets.

F J Neumann et al.

Circulation, 95(10), 2387-2394 (1997-05-20)

Activated platelets tether and activate myeloid leukocytes. To investigate the potential relevance of this mechanism in acute myocardial infarction (AMI), we examined cytokine induction by leukocyte-platelet adhesion and the occurrence of leukocyte-platelet conjugates in patients with AMI. We obtained peripheral

グリシン

meets analytical specification of Ph. Eur., BP, USP, 99-101% (based on anhydrous substance)

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この商品について

主要文書

特性

InChI key

InChI

SMILES string

assay

form

quality

technique(s)

impurities

ign. residue

loss

color

pH

pKa (25 °C)

mp

solubility

anion traces

suitability

Quality Level

Gene Information

関連するカテゴリー

詳細

Application

Biochem/physiol Actions

安全性情報

保管分類

wgk

flash_point_f

flash_point_c

ppe

適用法令

15527-6X500G-R: + 15527-6X2.5KG-R: + 15527-2.5KG-R: + 15527-BULK-R: + 15527-6X1KG-R: + 15527-1KG-R: + 15527-500G-R: + 15527-25KG-R: + 15527-50KG-R: + 15527-VAR-R:

資料

試験成績書（COA）

以前この製品を購入いただいたことがある場合

参考文献

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