ligand
pomalidomide
Quality Segment
reaction suitability
reaction type: PROTAC formation
parameter
up to 0.1 mmol scale
SMILES string
[s]1cnc(c1c2ccc(cc2)CNC(=O)[C@H]3N(C[C@@H](C3)O)C(=O)[C@@H](NC(=O)CCOCCC(=O)O)C(C)(C)C)C
InChI key
HVPZHRHEHKZOOJ-TYBLODHISA-N
General description
Reagent-cartridge CRBN-PEG5 is a reagent cartridge for the Synple 2 Automated Synthesizer that enables the synthesis of molecules for targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. The cartridge contains all necessary reagents for linking the user selected aldehyde or ketone to the amine terminated linker through a reductive amination. This cartridge features a Cereblon (CRBN) recruiting ligand (pomalidomide) and PEG linker. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation.
Scale: up to 0.1 mmol
Linker: PEG5
E3 ligase target and ligand: Cereblon (CRBN), pomalidomide
Terminal functional group: amine
Compatible substrates: ketone, aldehyde
Cartridge contents:
Related Cartridges:
Learn more about the Synple automated synthesis platform.
Learn more about protein degradation.
Explore all our Protein Degrader Building Blocks
Features and Benefits of Synple Platform
Scale: up to 0.1 mmol
Linker: PEG5
E3 ligase target and ligand: Cereblon (CRBN), pomalidomide
Terminal functional group: amine
Compatible substrates: ketone, aldehyde
Cartridge contents:
- Reducing agent (supported cyanoborohydride)
- Base (supported triethylamine)
- SCX (for purification)
- Degrader building block linker reagent
Related Cartridges:
- SYNPLE-P001Reagent-cartridge CRBN-PEG1
- SYNPLE-P002Reagent-cartridge CRBN-PEG2
- SYNPLE-P003Reagent-cartridge CRBN-PEG3
- SYNPLE-P004Reagent-cartridge CRBN-PEG4
- SYNPLE-P021Reagent-cartridge VHL-PEG1
- SYNPLE-P022Reagent-cartridge VHL-PEG2
- SYNPLE-P023Reagent-cartridge VHL-PEG3
- SYNPLE-P024Reagent-cartridge VHL-PEG4
- SYNPLE-P025Reagent-cartridge VHL-PEG5
Learn more about the Synple automated synthesis platform.
Learn more about protein degradation.
Explore all our Protein Degrader Building Blocks
Features and Benefits of Synple Platform
- Time savings - pre-installed protocols have been highly optimized, which obviates the need for the user′s own reaction development and optimization
- Easy to use - protocols are loaded by simply scanning the cartridge; does not requires any programming knowledge
- Safety - all chemicals are contained in the system, minimizing the user′s exposure
- Set-up reaction in less than 5 minutes
- Small footprint
- Plug & Play system - simple installation
- Reaction temperatures from 25 °C - 80 °C
- Cartridges available for many different reactions
- Prefilled with all required reagents
- RFID chip containing optimized reaction protocol
Legal Information
Product of Synple Chem AG
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
저장 등급
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable