D3314
D-erythro-ジヒドロスフィンゴシン
≥98%
別名:
スフィンガニン
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この商品について
実験式（ヒル表記法）:
C18H39NO2
CAS番号:
分子量:
301.51
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
製品名
D-erythro-ジヒドロスフィンゴシン, ≥98%
InChI
1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18+/m0/s1
SMILES string
OC[C@@](N)([H])[C@]([H])(O)CCCCCCCCCCCCCCC
InChI key
OTKJDMGTUTTYMP-ZWKOTPCHSA-N
biological source
synthetic (organic)
assay
≥98%
form
solid
color
white
solubility
DMSO: 25 mg/mL (warm)
ethanol: 25 mg/mL (warm)
lipid type
sphingolipids
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
スフィンゴシンの生合成前駆体で、プロテインキナ-ゼCを阻害します。
D-erythro-Dihydrosphingosine is a natural stereoisomer. The levels of dihydrosphingosine (DHS) is increased during unfolded protein response (UPR).
Application
D-erythro-Dihydrosphingosine has been used:
- as a standard lipid in quantification assay
- in kinetics assay
- to determine serine palmitoyl transferase activity
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
D3314-BULK: + D3314-10MG: + D3314-50MG: + D3314-50MG-PW: + D3314-10MG-PW: + D3314-VAR:
jan
The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms
Tam AB, et al.
Developmental Cell, 46(3), 327-343 (2018)
The Lipid Status in Patients with Ulcerative Colitis: Sphingolipids are Disease-Dependent Regulated.
Sarah Bazarganipour et al.
Journal of clinical medicine, 8(7) (2019-07-07)
The factors that contribute to the development of ulcerative colitis (UC), are still not fully identified. Disruption of the colon barrier is one of the first events leading to invasion of bacteria and activation of the immune system. The colon
Birgitte Lindegaard et al.
PloS one, 13(1), e0186755-e0186755 (2018-01-18)
Interleukin (IL)-18 is involved in regulation of lipid and glucose metabolism. Mice lacking whole-body IL-18 signalling are prone to develop weight gain and insulin resistance, a phenotype which is associated with impaired fat oxidation and ectopic skeletal muscle lipid deposition.
Disruption of sphingolipid metabolism augments ceramide-induced autophagy in preeclampsia
Melland-Smith M, et al.
Autophagy, 11(4), 653-669 (2015)
Ruzica Jurakic Toncic et al.
International journal of molecular sciences, 21(6) (2020-03-19)
Dysfunctional skin barrier plays a key role in the pathophysiology of atopic dermatitis (AD), a common inflammatory skin disease. Altered composition of ceramides is regarded as a major cause of skin barrier dysfunction, however it is not clear whether these
関連コンテンツ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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