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G3295

GW0742

Name: GW0742
Brand: SIGMA

≥98% (HPLC), selective PPARδ agonist, powder

Synonyme(s) :

4-[2-(3-Fluoro-4-trifluoromethyl-phenyl)-4-methyl-thiazol-5-ylmethylsulfanyl]- 2-methyl-phenoxy}-acetic acid

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A propos de cet article

Formule empirique (notation de Hill) :

C₂₁H₁₇F₄NO₃S₂

Numéro CAS:

317318-84-6

Poids moléculaire :

471.49

UNSPSC Code:

12352200

PubChem Substance ID:

24895123

NACRES:

NA.77

MDL number:

MFCD07369423

Assay:

≥98% (HPLC)

Form:

powder

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Propriétés

Nom du produit

GW0742, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white

mp

134.5-135.5 °C

solubility

DMSO: >5 mg/mL, H₂O: insoluble

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

Cc1cc(SCc2sc(nc2C)-c3ccc(c(F)c3)C(F)(F)F)ccc1OCC(O)=O

InChI

1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28)

InChI key

HWVNEWGKWRGSRK-UHFFFAOYSA-N

Gene Information

human ... PPARA(5465), PPARD(5467), PPARG(5468)

Description

Biochem/physiol Actions

GW0742 is a highly selective PPARδ agonist.

GW0742 is a highly selective PPARδ agonist. EC₅₀= 1 nM vs 1 μM and 2 μM for PPARα and PPARγ, respectively.

Features and Benefits

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from GlaxoSmithKline

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c