I1896
インターロイキン-13 マウス由来
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
別名:
IL-13
製品名
インターロイキン-13 マウス由来, ≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
biological source
mouse
recombinant
expressed in E. coli
assay
≥97% (SDS-PAGE)
form
lyophilized powder
potency
1-10 ng/mL EC50
mol wt
11.5 kDa (predicted; 9 kDa under reducing conditions)
packaging
pkg of 5 μg
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
mouse ... Il13(16163)
Biochem/physiol Actions
インタ-ロイキン-13は、ヒトおよびマウスの活性化Th2細胞によって産生される多機能性のサイトカインです。IL-13の大部分は132アミノ酸、分子量10,000ダルトンの非グリコシル化型タンパク質として分泌されます。マウスIL-13遺伝子の4.3kbのDNAフラグメントの配列が決定されており、第11染色体のマッピングで単一コピ-として生じています。ヒトの場合、IL-13遺伝子の4.6 kbのDNAフラグメントが単一コピ-として生じており、第5染色体に位置しています。IL-13はB細胞の増殖を誘導するとともに、IgEのスイッチングを引き起こします。ヒトおよびマウスIL-13産物の増殖活性は、ヒト赤白血病細胞株TF-1の培養で試験されています。
Physical form
凍結乾燥品 (PBS溶液, 0.25mg BSA含有, 0.2μmフィルタ-滅菌済み)。
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Luke Hatchwell et al.
Thorax, 70(9), 854-861 (2015-06-26)
Asthma exacerbations represent a significant disease burden and are commonly caused by rhinovirus (RV), which is sensed by Toll-like receptors (TLR) such as TLR7. Some asthmatics have impaired interferon (IFN) responses to RV, but the underlying mechanisms of this clinically
Gui Yang et al.
The Journal of biological chemistry, 290(20), 12858-12867 (2015-04-04)
Restoration of the antigen (Ag)-specific immune tolerance in an allergic environment is refractory. B cells are involved in immune regulation. Whether B cells facilitate the generation of Ag-specific immune tolerance in an allergic environment requires further investigation. This paper aims
Kihyuk Shin et al.
Clinical and experimental medicine, 15(3), 233-244 (2014-06-14)
The leukotrienes (LTs) enhance allergen- and interleukin (IL)-13-dependent allergic lung inflammatory disease. However, the precise requirement of LTs and the mechanism by which they elicit allergic lung responses remain uncertain. To clarify the involvement of LTs in respiratory allergen- and
C Abrial et al.
British journal of pharmacology, 172(17), 4319-4330 (2015-06-05)
15-Lipoxygenase (15-LOX) activity is associated with inflammation and immune regulation. The objectives of the present study were to investigate the expression of 15-LOX-1 and 15-LOX-2 and evaluate the enzymes' roles in the polarization of human lung macrophages (LMs) in response
Haixia Zhao et al.
Toxicology and applied pharmacology, 279(3), 311-321 (2014-07-16)
M2 macrophage polarization is implicated in colorectal cancer development. Isoliquiritigenin (ISL), a flavonoid from licorice, has been reported to prevent azoxymethane (AOM) induced colon carcinogenesis in animal models. Here, in a mouse model of colitis-associated tumorigenesis induced by AOM/dextran sodium
資料
Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.
関連コンテンツ
Instructions
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